Harnessing nuclear receptors to modulate hepatic stellate cell activation for liver fibrosis resolution
文献类型：期刊论文
| 作者 | Sun, Yaxin2,3,4; Yuan, Xiaoyan2,3,4; Hu, Zhenhua1,3; Li, Yuanyuan2,3,4 |
| 刊名 | BIOCHEMICAL PHARMACOLOGY
 |
| 出版日期 | 2025-02-01 |
| 卷号 | 232页码:15 |
| 关键词 | Nuclear receptors Hepatic stellate cell Liver fibrosis MASH MAFLD Resmetirom |
| ISSN号 | 0006-2952 |
| DOI | 10.1016/j.bcp.2024.116730 |
| 通讯作者 | Hu, Zhenhua(huzhenhua0577@zidd.ac.cn) ; Li, Yuanyuan(liyuanyuan@simm.ac.cn) |
| 英文摘要 | With the recent approval of Resmetirom as the first drug targeting nuclear receptors for metabolic dysfunctionassociated steatohepatitis (MASH), there is promising way to treat MASH-associated liver fibrosis. However, liver fibrosis can arise from various pathogenic factors, and effective treatments for fibrosis due to other causes remain elusive. The activation of hepatic stellate cells (HSCs) represents a central link in the pathogenesis of hepatic fibrosis. Therefore, harnessing nuclear receptors to modulate HSC activation may be an effective approach to resolving the complex liver fibrosis caused by various factors. In this comprehensive review, we systematically explore the structure and physiological functions of nuclear receptors, shedding light on their multifaceted roles in HSC activation. Recent advancements in drug development targeting nuclear receptors are discussed, providing insights into their potential as rational and effective therapeutic targets for modulating HSC activation in the context of liver fibrosis. By elucidating the intricate interplay between nuclear receptors and HSC activation, this review contributes to the discovery of new nuclear receptor targets in HSCs for resolving hepatic fibrosis. |
| WOS关键词 | FARNESOID-X RECEPTOR ; FREE-CHOLESTEROL ACCUMULATION ; ALPHA GENE-EXPRESSION ; BILE-ACID RECEPTORS ; PPAR-GAMMA ; LIPID-METABOLISM ; THYROID-HORMONES ; NONALCOHOLIC STEATOHEPATITIS ; TRANSCRIPTIONAL REGULATORS ; CONTROLLED-TRIAL |
| 资助项目 | National Natural Science Foundation of China[82104252] ; National Natural Science Foundation of China[82473985] ; Shanghai Pujiang Program[21PJ1415600] ; Guangdong Basic and Applied Basic Research Founda-tion[2022A1515010491] ; Zhongshan Municipal Bureau of Science and Technology |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001397667800001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315896]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Hu, Zhenhua; Li, Yuanyuan |
| 作者单位 | 1.Sun Yat Sen Univ, Nanfang Coll, Dept Hlth & Nursing, Guangzhou, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Yaxin,Yuan, Xiaoyan,Hu, Zhenhua,et al. Harnessing nuclear receptors to modulate hepatic stellate cell activation for liver fibrosis resolution[J]. BIOCHEMICAL PHARMACOLOGY,2025,232:15. |
| APA | Sun, Yaxin,Yuan, Xiaoyan,Hu, Zhenhua,&Li, Yuanyuan.(2025).Harnessing nuclear receptors to modulate hepatic stellate cell activation for liver fibrosis resolution.BIOCHEMICAL PHARMACOLOGY,232,15. |
| MLA | Sun, Yaxin,et al."Harnessing nuclear receptors to modulate hepatic stellate cell activation for liver fibrosis resolution".BIOCHEMICAL PHARMACOLOGY 232(2025):15. |
入库方式： OAI收割
来源：上海药物研究所
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