Stimuli-Responsive Nano Drug Delivery Systems for the Treatment of Neurological Diseases
文献类型：期刊论文
| 作者 | Dai, Xi-jian4,5; Li, Wen-Jia1,2,3; Xie, Dong-Dong2; Liu, Bi-xia4; Gong, Lianggeng4,5; Han, Hai-Hao1,2,3 |
| 刊名 | SMALL
 |
| 出版日期 | 2025-01-22 |
| 页码 | 21 |
| 关键词 | drug release nanomaterial neurological diseases stimulus-responsive nanodrug delivery system targeted therapy |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.202410030 |
| 通讯作者 | Dai, Xi-jian(daixjdoctor@126.com) ; Gong, Lianggeng(gong111999@126.com) ; Han, Hai-Hao(hanhaihao@simm.ac.cn) |
| 英文摘要 | Nanomaterials with unparalleled physical and chemical attributes have become a cornerstone in the field of nanomedicine delivery. These materials can be engineered into various functionalized nanocarriers, which have become the focus of research. Stimulus-responsive nanodrug delivery systems (SRDDS) stand out as a sophisticated class of nanocarriers that can release drugs in response to environmental cues. Due to the complex pathogenesis and the multifaceted pathological environment of the nervous system, developing accurate and effective drug therapy with low side-effects is a formidable task. In recent years, SRDDS have been widely used in the treatment of neurological diseases. By customizing SRDDS to align with the specific microenvironment of the nervous system tissues or external stimulation, the efficacy of drug delivery can be enhanced. This review provides an in-depth look at the characteristics of the microenvironment of neurological diseases and highlights case studies of SRDDS tailored to treat these disorders based on the unique stimulation criteria of nervous system tissues or external triggers. Additionally, this review provides a comprehensive overview of the progress and future prospects of SRDDS technology in the treatment of neurological diseases, providing valuable guidance for its transition from fundamental research to clinical application. |
| WOS关键词 | BLOOD-BRAIN-BARRIER ; PHOTOTHERMAL THERAPY ; RECENT PROGRESS ; PH ; MECHANISMS ; DIAGNOSIS ; NANOMATERIALS ; NANOTECHNOLOGY ; NANOPARTICLES ; BIOMATERIALS |
| 资助项目 | Science Foundation for Distinguished Young Scholars of Jiangxi Province ; National Natural Science Foundation of China[82460341] ; National Natural Science Foundation of China[22107029] ; National Natural Science Foundation of China[22377135] ; Natural Science Foundation of Jiangxi Province[20224BAB216077] ; Hunan Province[2022JJ40417] ; Hunan Province[2021SK52203] ; Key Laboratory of Medical Imaging and Artificial Intelligence of Hunan Province[YXZN2021003] ; Taishan Scholars Program[tsqn202312305] ; Young Elite Scientists Sponsorship Program by Chinese Chemical Society ; Fundamental Research Projects of Science & Technology Innovation and development Plan in Yantai City[2023JCYJ059] ; Key R&D Program of Shandong Province, China[2024CXPT028] ; Shandong Laboratory Program[SYS202205] ; [20242BAB23086] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001401315300001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315923]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Dai, Xi-jian; Gong, Lianggeng; Han, Hai-Hao |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Stake Key Lab Chem Biol, Mol Imaging Ctr,Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 4.Jiangxi Prov Key Lab Intelligent Med Imaging, Nanchang 330006, Peoples R China 5.Nanchang Univ, Affiliated Hosp 2, Jiangxi Med Coll, Dept Radiol, Nanchang 330006, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dai, Xi-jian,Li, Wen-Jia,Xie, Dong-Dong,et al. Stimuli-Responsive Nano Drug Delivery Systems for the Treatment of Neurological Diseases[J]. SMALL,2025:21. |
| APA | Dai, Xi-jian,Li, Wen-Jia,Xie, Dong-Dong,Liu, Bi-xia,Gong, Lianggeng,&Han, Hai-Hao.(2025).Stimuli-Responsive Nano Drug Delivery Systems for the Treatment of Neurological Diseases.SMALL,21. |
| MLA | Dai, Xi-jian,et al."Stimuli-Responsive Nano Drug Delivery Systems for the Treatment of Neurological Diseases".SMALL (2025):21. |
入库方式： OAI收割
来源：上海药物研究所
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