Novel functionalized benzimidazole-salicylic acid derivatives: synthesis, photophysical characteristics and biological applications
文献类型：期刊论文
| 作者 | Yan, Xue4,7; Gao, Li-Xin5; Cao, Zi-Tong2,5; Gan, Su-Ya7; Fu, Yi-Qiu1; Li, Jia5 ; Xiang, Da-Jun3; Zhou, Yu-Bo6; Wang, Wen-Long4,7
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| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
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| 出版日期 | 2025-02-06 |
| 页码 | 11 |
| ISSN号 | 2050-750X |
| DOI | 10.1039/d4tb02524e |
| 通讯作者 | Xiang, Da-Jun(xiangdjxshospital@yeah.net) ; Zhou, Yu-Bo(ybzhou@simm.ac.cn) ; Wang, Wen-Long(wenlongwang@jiangnan.edu.cn) |
| 英文摘要 | Although the benzimidazole moiety is a versatile heterocyclic unit that has been widely applied in optical materials and medicinal chemistry, there are few bifunctional small-molecule benzimidazole derivatives with bio-activity and fluorescence. In this work, a series of novel benzimidazole-salicylic acid molecules were designed and synthesized; their optical properties were evaluated and their potential biological application was explored. The representative compound 5q exhibited excellent fluorescence properties, displaying blue imaging in HeLa cells and zebrafish. Additionally, it exhibited high selectivity for Fe3+ ions and demonstrated a notable inhibitory activity with IC50 = 6.86 +/- 2.82 mu M against SHP1PTP. Further effort was applied to explore the potential capability of compound 5q to reactivate the activity of SHP1 when inhibited by Fe3+ ions, indicating that compound 5q could be a fluorescent modulator to adjust SHP1 enzyme activity in biological systems. |
| WOS关键词 | AGGREGATION-INDUCED EMISSION ; SMALL-MOLECULE INHIBITOR ; FLUORESCENT SENSOR ; OPTICAL-PROPERTIES ; TYROSINE ; CANCER ; PHOSPHATASES ; IRON(III) ; METALS ; POTENT |
| 资助项目 | National Natural Science Foundation of China[22277043] ; National Natural Science Foundation of China[JUSRP121065] ; Fundamental Research Funds for the Central Universities[JSSCBS20210848] ; High Level Personnel Project of Jiangsu Province ; BioDuro-Sundia in Wuxi and high-performance computing cluster platform of the School of Biotechnology in Jiangnan University |
| WOS研究方向 | Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001420685400001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316209]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xiang, Da-Jun; Zhou, Yu-Bo; Wang, Wen-Long |
| 作者单位 | 1.Beijing Chemp Biotechnol Co Ltd, Beijing 100010, Peoples R China 2.China Pharmaceut Univ, Inst Pharmaceut Sci, Nanjing 210009, Jiangsu, Peoples R China 3.Xishan Peoples Hosp Wuxi City, Wuxi 214105, Jiangsu, Peoples R China 4.Jiangnan Univ, Sch Chem & Mat Engn, Wuxi 214122, Jiangsu, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Stake Key Lab Chem Biol, Shanghai 201203, Peoples R China 6.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, SSIP Healthcare & Med Demonstrat Zone, Zhongshan 528400, Peoples R China 7.Jiangnan Univ, Sch Life Sci & Hlth Engn, Wuxi 214122, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Xue,Gao, Li-Xin,Cao, Zi-Tong,et al. Novel functionalized benzimidazole-salicylic acid derivatives: synthesis, photophysical characteristics and biological applications[J]. JOURNAL OF MATERIALS CHEMISTRY B,2025:11. |
| APA | Yan, Xue.,Gao, Li-Xin.,Cao, Zi-Tong.,Gan, Su-Ya.,Fu, Yi-Qiu.,...&Wang, Wen-Long.(2025).Novel functionalized benzimidazole-salicylic acid derivatives: synthesis, photophysical characteristics and biological applications.JOURNAL OF MATERIALS CHEMISTRY B,11. |
| MLA | Yan, Xue,et al."Novel functionalized benzimidazole-salicylic acid derivatives: synthesis, photophysical characteristics and biological applications".JOURNAL OF MATERIALS CHEMISTRY B (2025):11. |
入库方式： OAI收割
来源：上海药物研究所
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