Revolutionizing fixed-dose combinations with long-acting microsphere
文献类型：期刊论文
| 作者 | Hu, Zhenhua4; Xiao, Xiao3,4; Zhang, Guiyun3,4; Li, Yuanyuan1,2,3,4 |
| 刊名 | EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
 |
| 出版日期 | 2025-04-01 |
| 卷号 | 207页码:12 |
| 关键词 | Fixed-dose combinations Microsphere Chronic disease Long-acting |
| ISSN号 | 0928-0987 |
| DOI | 10.1016/j.ejps.2025.107032 |
| 通讯作者 | Li, Yuanyuan(liyuanyuan@simm.ac.cn) |
| 英文摘要 | Combination therapy, involving the concurrent use of multiple medications, has become crucial for managing complex diseases with diverse pathological mechanisms. Fixed-Dose Combinations (FDCs) are formulated to leverage the synergistic effects of multiple drugs, thereby enhancing therapeutic outcomes. However, conventional FDCs typically maintain therapeutic effects for only up to 24 h and require frequent dosing, which often results in patient non-compliance and inconsistent treatment responses, especially in chronic diseases. This highlights the urgent need for long-acting FDCs that can provide sustained drug release over extended periods-weeks, months, or even years-thereby reducing dosing frequency and enhancing patient adherence. Microspheres, with their ability to encapsulate and release multiple medications in predefined patterns, are highly advantageous for developing long-acting FDC drugs. This review emphasizes the increasing demand for longacting FDC drugs that ensure sustained drug release, reduce dosing frequency, and ultimately improve patient adherence. We also highlight the potential of microsphere technology, which enables precise encapsulation and sustained release of multiple medications, as a promising approach for revolutionizing long-acting FDCs with enhanced therapeutic outcomes. |
| WOS关键词 | OF-THE-ART ; DRUG-DELIVERY ; SOLVENT EXTRACTION/EVAPORATION ; BIODEGRADABLE MICROSPHERES ; POLYMERIC MICROSPHERES ; PLGA MICROSPHERES ; ACID MICROSPHERES ; SUSTAINED-RELEASE ; THERAPY ; MICROENCAPSULATION |
| 资助项目 | National Natural Science Foundation of China[82104252] ; National Natural Science Foundation of China[82473985] ; Shanghai Pujiang Program[21PJ1415600] ; Guangdong Basic and Applied Basic Research Founda-tion[2022A1515010491] ; Zhongshan Municipal Bureau of Science and Technology |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001424861900001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316293]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Yuanyuan |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Guizhou Med Univ, Sch Pharm, Guiyang 550025, Peoples R China 4.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Zhenhua,Xiao, Xiao,Zhang, Guiyun,et al. Revolutionizing fixed-dose combinations with long-acting microsphere[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2025,207:12. |
| APA | Hu, Zhenhua,Xiao, Xiao,Zhang, Guiyun,&Li, Yuanyuan.(2025).Revolutionizing fixed-dose combinations with long-acting microsphere.EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,207,12. |
| MLA | Hu, Zhenhua,et al."Revolutionizing fixed-dose combinations with long-acting microsphere".EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 207(2025):12. |
入库方式： OAI收割
来源：上海药物研究所
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