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Comprehensive MALDI mass spectrometry imaging of tumor regions post-neoadjuvant therapy

文献类型：期刊论文

作者Xu, Hui5; Zhang, Qian4,5; Yuan, Jie4; Xu, Jianfeng2; Sui, Jian1; Liu, Jia3,4
刊名ANALYTICAL AND BIOANALYTICAL CHEMISTRY
出版日期2025-02-20
页码8
关键词Neoadjuvant chemotherapy Matrix-assisted laser desorption ionization mass spectrometer Necrotic region Spatial metabolomics
ISSN号1618-2642
DOI10.1007/s00216-025-05785-4
通讯作者Liu, Jia(jia.liu@simm.ac.cn)
英文摘要The spatial metabolic analysis of tumor tissues following neoadjuvant chemotherapy (NAC) is critical for understanding chemotherapy-induced metabolic changes. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) offers a powerful tool for revealing spatially resolved metabolic profiles within tissues. However, necrotic regions in post-NAC tissues are fragile, creating challenges for sample preparation and MALDI MSI analysis. In this study, we introduce an optimized workflow employing conductive tape to stabilize tissue samples during sectioning and MALDI MSI analysis, preserving necrotic areas while maintaining tissue integrity. Using this technique, we successfully mapped metabolic alterations across necrotic and viable regions of post-NAC tumor tissues, providing new insights into metabolic changes that occur after chemotherapy. Our findings establish MALDI MSI as a valuable tool for spatially resolved metabolomics in post-NAC tumor tissues, offering insights into chemotherapy-induced metabolic changes.
资助项目National Natural Science Foundation of China
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:001426433800001
出版者SPRINGER HEIDELBERG
源URL[http://119.78.100.183/handle/2S10ELR8/316296]  
专题中国科学院上海药物研究所
通讯作者Liu, Jia
作者单位1.Shanghai Zenith Biotechnol Co LTD, Shanghai 201203, Peoples R China
2.Fudan Univ, Huashan Hosp, Dept Gen Surg, Hepatobiliary Surg, Shanghai 200040, Peoples R China
3.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310058, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
5.Yantai Univ, Univ Shandong, Collaborat Innovat Ctr Adv Drug Delivery Syst & Bi, Sch Pharm,Key Lab Mol Pharmacol & Drug Evaluat,Min, Yantai 264005, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Hui,Zhang, Qian,Yuan, Jie,et al. Comprehensive MALDI mass spectrometry imaging of tumor regions post-neoadjuvant therapy[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2025:8.
APA Xu, Hui,Zhang, Qian,Yuan, Jie,Xu, Jianfeng,Sui, Jian,&Liu, Jia.(2025).Comprehensive MALDI mass spectrometry imaging of tumor regions post-neoadjuvant therapy.ANALYTICAL AND BIOANALYTICAL CHEMISTRY,8.
MLA Xu, Hui,et al."Comprehensive MALDI mass spectrometry imaging of tumor regions post-neoadjuvant therapy".ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2025):8.

入库方式： OAI收割

来源：上海药物研究所

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