Current landscape of metal-organic framework-mediated nucleic acid delivery and therapeutics
文献类型：期刊论文
| 作者 | Feng, Shiwei2; Li, Yan2; Tan, Zheng2; Shen, Shiyang1,2 |
| 刊名 | INTERNATIONAL JOURNAL OF PHARMACEUTICS
 |
| 出版日期 | 2025-03-15 |
| 卷号 | 672页码:21 |
| 关键词 | Metal-organic frameworks Nucleic acids Nanocarrier Drug delivery |
| ISSN号 | 0378-5173 |
| DOI | 10.1016/j.ijpharm.2025.125295 |
| 通讯作者 | Tan, Zheng(tanzheng314@zidd.ac.cn) ; Shen, Shiyang(shenshiyang@simm.ac.cn) |
| 英文摘要 | Nucleic acid drugs utilize DNA or RNA molecules to modulate abnormal gene expression or protein translation in cells, enabling precise treatment for specific conditions. In recent years, nucleic acid drugs have demonstrated tremendous potential in vaccine development and treating genetic disorders. Currently, the primary carriers for clinically approved nucleic acid therapies include lipid nanoparticles and viral vectors. Beyond that, metal-organic frameworks (MOFs) are highly ordered, porous nanomaterials formed through the self-assembly of metal ions and organic ligands via coordination bonds. Their porosity structure offers great loading efficiency, stability, tunability, and biocompatibility, making them an attractive option for nucleic acid delivery. Given the research on MOFs as nucleic acid carriers has garnered significant attention in recent years, this review provides an overview of the therapeutic strategies and advancements in MOF-mediated nucleic acid delivery. The unique properties of various MOF carriers are introduced, and different approaches for nucleic acid loading are parallelly compared. Moreover, a systematic classification based on the type of nucleic acid cargo loaded in MOFs and corresponding applications is thoroughly described. This summary outlines the unique mechanisms through MOFs enhance nucleic acid delivery and emphasizes their substantial impact on therapeutic efficacy. In addition, the utilization of MOF-mediated nucleic acid treatment in combination with other therapies against malignant tumors is discussed in particular. Finally, an outlook on the challenges and potential opportunities of this technology in future translational production and clinical implementation is presented and explored. |
| WOS关键词 | ANTISENSE OLIGONUCLEOTIDES ; DRUG ; RNA ; NANOPARTICLE ; TEMPERATURE ; MACROPHAGES ; EFFICIENT |
| 资助项目 | National Natural Science Foundation of China[82104090] ; Natural Science Foundation of Jiangsu Province, China[BK20210425] ; National Key Laboratory of Advanced Drug Delivery and Release Systems[DSQZ-QN-202302] ; Project of High-level New R D Institute[2019B090904008] ; Department of Science and Technology of Guangdong Province, China[2021B0909050003] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001426078700001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316305]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Tan, Zheng; Shen, Shiyang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Preparat Res Ctr, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, Shiwei,Li, Yan,Tan, Zheng,et al. Current landscape of metal-organic framework-mediated nucleic acid delivery and therapeutics[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2025,672:21. |
| APA | Feng, Shiwei,Li, Yan,Tan, Zheng,&Shen, Shiyang.(2025).Current landscape of metal-organic framework-mediated nucleic acid delivery and therapeutics.INTERNATIONAL JOURNAL OF PHARMACEUTICS,672,21. |
| MLA | Feng, Shiwei,et al."Current landscape of metal-organic framework-mediated nucleic acid delivery and therapeutics".INTERNATIONAL JOURNAL OF PHARMACEUTICS 672(2025):21. |
入库方式： OAI收割
来源：上海药物研究所
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