π-HuB: the proteomic navigator of the human body
文献类型：期刊论文
| 作者 | He, Fuchu132,133; Aebersold, Ruedi131; Baker, Mark S.130; Bian, Xiuwu127,128,129; Bo, Xiaochen126; Chan, Daniel W.124,125; Chang, Cheng133; Chen, Luonan123; Chen, Xiangmei122; Chen, Yu-Ju121 |
| 刊名 | NATURE
 |
| 出版日期 | 2024-12-12 |
| 卷号 | 636期号:8042页码:322-331 |
| ISSN号 | 0028-0836 |
| DOI | 10.1038/s41586-024-08280-5 |
| 英文摘要 | The human body contains trillions of cells, classified into specific cell types, with diverse morphologies and functions. In addition, cells of the same type can assume different states within an individual's body during their lifetime. Understanding the complexities of the proteome in the context of a human organism and its many potential states is a necessary requirement to understanding human biology, but these complexities can neither be predicted from the genome, nor have they been systematically measurable with available technologies. Recent advances in proteomic technology and computational sciences now provide opportunities to investigate the intricate biology of the human body at unprecedented resolution and scale. Here we introduce a big-science endeavour called pi-HuB (proteomic navigator of the human body). The aim of the pi-HuB project is to (1) generate and harness multimodality proteomic datasets to enhance our understanding of human biology; (2) facilitate disease risk assessment and diagnosis; (3) uncover new drug targets; (4) optimize appropriate therapeutic strategies; and (5) enable intelligent healthcare, thereby ushering in a new era of proteomics-driven phronesis medicine. This ambitious mission will be implemented by an international collaborative force of multidisciplinary research teams worldwide across academic, industrial and government sectors. |
| WOS关键词 | CHINA PUSHES ; DISEASE ; ATLAS ; DRAFT |
| 资助项目 | Ministry of Science and Technology of the People's Republic of China[2020YFE0202200] ; National Natural Science Foundation of China[32088101] ; National Institutes of Health[P30ES017885-11-S1] ; National Institutes of Health[U24CA271037] ; Guangzhou Development District |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001386354300001 |
| 出版者 | NATURE PORTFOLIO |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315555]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | He, Fuchu; Aebersold, Ruedi; Yun, Tao |
| 作者单位 | 1.Guangzhou Med Univ, Guangzhou Inst Resp Hlth, State Key Lab Resp Dis, Affiliated Hosp 1, Guangzhou, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 3, Dept Urol, Beijing, Peoples R China 3.Peking Univ Int Canc Inst, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Atmospher Phys, Beijing, Peoples R China 5.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China 6.Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Dept Liver Surg, Canc Ctr, Guangzhou, Peoples R China 7.Peking Univ, Biomed Pioneering Innovat Ctr BIOPIC, Beijing, Peoples R China 8.Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Key Lab Syst Biomed, Minist Educ, Shanghai, Peoples R China 9.Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen, Peoples R China 10.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Fuchu,Aebersold, Ruedi,Baker, Mark S.,et al. π-HuB: the proteomic navigator of the human body[J]. NATURE,2024,636(8042):322-331. |
| APA | He, Fuchu.,Aebersold, Ruedi.,Baker, Mark S..,Bian, Xiuwu.,Bo, Xiaochen.,...&Zhang, Zemin.(2024).π-HuB: the proteomic navigator of the human body.NATURE,636(8042),322-331. |
| MLA | He, Fuchu,et al."π-HuB: the proteomic navigator of the human body".NATURE 636.8042(2024):322-331. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。