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Bioengineered therapeutic systems for improving antitumor immunity

文献类型：期刊论文

作者Cao, Ying4,5,6; Yan, Wenlu3,5,6; Yi, Wenzhe3,5,6; Yin, Qi2,3,5,6; Li, Yaping1,2,3,5,6
刊名NATIONAL SCIENCE REVIEW
出版日期2025-01-06
卷号12期号:1页码:23
关键词immunotherapy biological organisms gene engineering synthetic biology surface engineering
ISSN号2095-5138
DOI10.1093/nsr/nwae404
英文摘要Immunotherapy, a monumental advancement in antitumor therapy, still yields limited clinical benefits owing to its unguaranteed efficacy and safety. Therapeutic systems derived from cellular, bacterial and viral sources possess inherent properties that are conducive to antitumor immunotherapy. However, crude biomimetic systems have restricted functionality and may produce undesired toxicity. With advances in biotechnology, various toolkits are available to add or subtract certain properties of living organisms to create flexible therapeutic platforms. This review elaborates on the creation of bioengineered systems, via gene editing, synthetic biology and surface engineering, to enhance immunotherapy. The modifying strategies of the systems are discussed, including equipment for navigation and recognition systems to improve therapeutic precision, the introduction of controllable components to control the duration and intensity of treatment, the addition of immunomodulatory components to amplify immune activation, and the removal of toxicity factors to ensure biosafety. Finally, we summarize the advantages of bioengineered immunotherapeutic systems and possible directions for their clinical translation. This review presents an overview of bioengineered therapeutic systems based on cells/bacteria/viruses for cancer immunotherapy, with a particular emphasis on their engineering strategies and acquired functions.
WOS关键词ARMED ONCOLYTIC ADENOVIRUS ; PHASE-I ; GENE-THERAPY ; STEM-CELLS ; T-CELLS ; MACROPHAGES ; LIPOPOLYSACCHARIDE ; IMMUNOTHERAPY ; NANOPARTICLES ; LYMPHOCYTES
资助项目National Key R&D Program of China[2022YFC3401400] ; National Natural Science Foundation of China[32130058] ; National Natural Science Foundation of China[32171315] ; National Natural Science Foundation of China[31930066] ; Shandong Provincial Natural Science Foundation[ZR2019ZD25] ; Shandong Laboratory Program[SYS202205]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:001390060000001
出版者OXFORD UNIV PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/315567]  
专题新药研究国家重点实验室
通讯作者Yin, Qi; Li, Yaping
作者单位1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264000, Peoples R China
2.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Jilin Univ, Sch Life Sci, Changchun 130012, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
6.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Cao, Ying,Yan, Wenlu,Yi, Wenzhe,et al. Bioengineered therapeutic systems for improving antitumor immunity[J]. NATIONAL SCIENCE REVIEW,2025,12(1):23.
APA Cao, Ying,Yan, Wenlu,Yi, Wenzhe,Yin, Qi,&Li, Yaping.(2025).Bioengineered therapeutic systems for improving antitumor immunity.NATIONAL SCIENCE REVIEW,12(1),23.
MLA Cao, Ying,et al."Bioengineered therapeutic systems for improving antitumor immunity".NATIONAL SCIENCE REVIEW 12.1(2025):23.

入库方式： OAI收割

来源：上海药物研究所

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