Ucp1 Ablation Improves Skeletal Muscle Glycolytic Function in Aging Mice
文献类型：期刊论文
| 作者 | Qiu, Jin7,8; Guo, Yuhan8; Guo, Xiaozhen6,7; Liu, Ziqi7,8; Li, Zixuan7,8; Zhang, Jun7,8; Cao, Yutang5; Li, Jiaqi4,6; Yu, Shuwu4,6; Xu, Sainan7,8 |
| 刊名 | ADVANCED SCIENCE
 |
| 出版日期 | 2024-11-21 |
| 页码 | 18 |
| 关键词 | aging creatine glycolytic function skeletal muscle thermogenic adipose tissue |
| DOI | 10.1002/advs.202411015 |
| 英文摘要 | Muscular atrophy is among the systematic decline in organ functions in aging, while defective thermogenic fat functionality precedes these anomalies. The potential crosstalk between adipose tissue and muscle during aging is poorly understood. In this study, it is showed that UCP1 knockout (KO) mice characterized deteriorated brown adipose tissue (BAT) function in aging, yet their glucose homeostasis is sustained and energy expenditure is increased, possibly compensated by improved inguinal adipose tissue (iWAT) and muscle functionality compared to age-matched WT mice. To understand the potential crosstalk, RNA-seq and metabolomic analysis were performed on adipose tissue and muscle in aging mice and revealed that creatine levels are increased both in iWAT and muscle of UCP1 KO mice. Interestingly, molecular analysis and metabolite tracing revealed that creatine biosynthesis is increased in iWAT while creatine uptake is increased in muscle in UCP1 KO mice, suggesting creatine transportation from iWAT to muscle. Importantly, creatine analog beta-GPA abolished the differences in muscle functions between aging WT and UCP1 KO mice, while UCP1 inhibitor alpha-CD improved muscle glycolytic function and glucose metabolism in aging mice. Overall, these results suggested that iWAT and skeletal muscle compensate for declined BAT function during aging via creatine metabolism to sustain metabolic homeostasis. |
| WOS关键词 | ADIPOSE-TISSUE ; CREATINE SUPPLEMENTATION ; ALPHA-CYCLODEXTRIN ; METABOLIC DYSFUNCTION ; THERMOGENESIS ; OBESITY ; CELL ; DIFFERENTIATION ; INFLAMMATION ; ACTIVATION |
| 资助项目 | National Natural Science Foundation of China ; National Key Research and Development Program of China[2023YFA1800400] ; Fundamental Research Funds for the Central Universities ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB39020600] ; China Postdoctoral Science Foundation[2022M721159] ; Natural Science Foundation of Chongqing[CSTB2022NSCQJQX0033] ; Science and Technology Commission of Shanghai Municipality[22ZR1421200] ; Science and Technology Commission of Shanghai, Science and Technology Innovation Action Plan[21140904300] ; ECNU public platform for Innovation ; [32222024] ; [32325024] ; [32271224] ; [32071148] ; [82222071] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001393218800001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315600]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Ma, Xinran; Xie, Cen; Xu, Lingyan |
| 作者单位 | 1.East China Normal Univ, Chongqing Inst, Chongqing Key Lab Precis Opt, Chongqing 401120, Peoples R China 2.East China Normal Univ, Shanghai Frontiers Sci Ctr Genome Editing & Cell T, Shanghai Key Lab Regulatory Biol, Shanghai 200241, Peoples R China 3.Southern Med Univ, Fengxian Cent Hosp, Dept Endocrinol & Metab, Shanghai 201499, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 7.East China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China 8.East China Normal Univ, Inst Biomed Sci, Shanghai Key Lab Regulatory Biol, Shanghai 200241, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qiu, Jin,Guo, Yuhan,Guo, Xiaozhen,et al. Ucp1 Ablation Improves Skeletal Muscle Glycolytic Function in Aging Mice[J]. ADVANCED SCIENCE,2024:18. |
| APA | Qiu, Jin.,Guo, Yuhan.,Guo, Xiaozhen.,Liu, Ziqi.,Li, Zixuan.,...&Xu, Lingyan.(2024).Ucp1 Ablation Improves Skeletal Muscle Glycolytic Function in Aging Mice.ADVANCED SCIENCE,18. |
| MLA | Qiu, Jin,et al."Ucp1 Ablation Improves Skeletal Muscle Glycolytic Function in Aging Mice".ADVANCED SCIENCE (2024):18. |
入库方式： OAI收割
来源：上海药物研究所
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