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Intratumoral lactic acid neutralization strategy for boosting chemoimmunotherapy using liposomal sodium bicarbonate

文献类型：期刊论文

作者Peng, Taoxing5,6; Shao, Xinyue4,5; Song, Wenqin3; Xu, Weihua5; Xiong, Wei2; He, Yihao5; Ding, Yang6; Huang, Yongzhuo1,2,3,4,5
刊名SCIENCE BULLETIN
出版日期2024-12-30
卷号69期号:24页码:3936-3948
关键词Sodium bicarbonate Lactic acid neutralization Tumor microenvironment normalization Chemoimmunotherapy PD-1 antibody Ion-trapping barrier
ISSN号2095-9273
DOI10.1016/j.scib.2024.08.042
英文摘要Glycolysis-related lactic acid overproduction creates an "ion-trapping" barrier and immunosuppressive tumor microenvironment that compromise effective intratumoral drug delivery and therapy. Therefore, normalization of tumor microenvironment via lactic acid neutralization can be a promising avenue for overcoming this therapeutic hurdle. In this study, the flexible liposomes loaded with sodium bicarbonate (NaHCO3@Flip) were used as a nano-adjuvant to boost chemoimmunotherapy. Their effects on assisting DOXIL and anti-programmed cell death protein 1 (PD-1) therapy were investigated. NaHCO3@Flip achieved deep tumor penetration, with the ability to neutralize lactic acid and normalize the acidic tumor microenvironment. NaHCO3@Flip is biosafe and can enhance cellular uptake efficiency of doxorubicin (DOX) by overcoming the ion-trapping barrier and amplify immunogenic cell death induced by DOX. The combination therapy of liposomal DOX and NaHCO3@Flip demonstrated enhanced inhibition of tumor growth. NaHCO3@Flip can also synergize with PD-1 antibody therapy. NaHCO3@Flip has the potential to serve as a therapeutic adjuvant for boosting chemoimmunotherapy by overcoming the ion-trapping effect and normalizing the tumor microenvironment. (c) 2024 Science China Press. Published by Elsevier B.V. and Science China Press. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
WOS关键词ANTITUMOR RESPONSES ; TUMOR ACIDITY ; PH ; MICROENVIRONMENT ; RIGIDITY ; ADAPTATION ; INCREASES ; DOXIL(R) ; DEATH
资助项目National Key Research and Development Program of China[2021YFC400600] ; National Key Research and Development Program of China[2022YFE0203600] ; National Natural Science Foundation of China[81925035] ; National Natural Science Foundation of China[82341232] ; National Natural Science Foundation of China[083GJHZ2023012FN] ; National Natural Science Foundation of China[083GJHZ2023021GC] ; Chinese Academy of Sciences, CAS President's International Fellowship Initiative[2024VBB0004] ; High-level Innovative Research Institute[2021B0909050003] ; Department of Science and Technology of Guangdong Province ; Zhongshan Municipal Bureau of Science and Technology[LJ2021001] ; Zhongshan Municipal Bureau of Science and Technology[CXTD2022011] ; Chinese Academy of Sciences ; Molecular Imaging Center and TEM Facility at Shanghai Institute of Materia Medica
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:001392200700001
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/315618]  
专题新药研究国家重点实验室
通讯作者Ding, Yang; Huang, Yongzhuo
作者单位1.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
6.China Pharmaceut Univ, Dept Pharmaceut, State Key Lab Nat Med, Nanjing 210009, Peoples R China
推荐引用方式
GB/T 7714		 Peng, Taoxing,Shao, Xinyue,Song, Wenqin,et al. Intratumoral lactic acid neutralization strategy for boosting chemoimmunotherapy using liposomal sodium bicarbonate[J]. SCIENCE BULLETIN,2024,69(24):3936-3948.
APA Peng, Taoxing.,Shao, Xinyue.,Song, Wenqin.,Xu, Weihua.,Xiong, Wei.,...&Huang, Yongzhuo.(2024).Intratumoral lactic acid neutralization strategy for boosting chemoimmunotherapy using liposomal sodium bicarbonate.SCIENCE BULLETIN,69(24),3936-3948.
MLA Peng, Taoxing,et al."Intratumoral lactic acid neutralization strategy for boosting chemoimmunotherapy using liposomal sodium bicarbonate".SCIENCE BULLETIN 69.24(2024):3936-3948.

入库方式： OAI收割

来源：上海药物研究所

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