Electrochemical Alkoxylation of Benzylic C(sp3)-H Bonds
文献类型：期刊论文
| 作者 | Zhao, Naixuan2,3; Xie, Geyao2,3; Zheng, Miao1,2; Chang, Shunzhen2,3; Zhang, Zhenwei3; He, Guoxue3; Zhou, Yu1,2,3
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| 刊名 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2025-01-07 |
| 页码 | 6 |
| 关键词 | Electrochemical Alkoxylation Benzylic C(sp(3))-H |
| ISSN号 | 1434-193X |
| DOI | 10.1002/ejoc.202401227 |
| 英文摘要 | We report an electrochemical process for the direct alkoxylation of benzylic C(sp(3))-H bonds without the need for external oxidants or metal catalysts. This environmentally friendly and sustainable synthetic strategy facilitates the alkoxylation of C(sp(3))-H in benzylic groups. The approach enables the late-stage incorporation of complex alkoxy groups into bioactive molecules, providing potential applications in the synthesis of celestolide derivatives. |
| WOS关键词 | MEDICINAL CHEMISTS TOOLBOX ; HYPERVALENT IODINE ; UNACTIVATED C(SP(3))-H ; C(SP(2))-H BONDS ; ANODIC-OXIDATION ; FUNCTIONALIZATION ; HYDROXYLATION ; ALCOHOLS ; ETHERS |
| 资助项目 | National Natural Science Foundation of China ; Shanghai Institute of Materia Medica, Chinese Academy of Sciences[SIMM0320231009] ; China Postdoctoral Science Foundation[2023M730821] ; Shandong Laboratory Program[SYS202205] ; [82373709] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001392483300001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315621]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | He, Guoxue; Zhou, Yu |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Naixuan,Xie, Geyao,Zheng, Miao,et al. Electrochemical Alkoxylation of Benzylic C(sp3)-H Bonds[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2025:6. |
| APA | Zhao, Naixuan.,Xie, Geyao.,Zheng, Miao.,Chang, Shunzhen.,Zhang, Zhenwei.,...&Zhou, Yu.(2025).Electrochemical Alkoxylation of Benzylic C(sp3)-H Bonds.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,6. |
| MLA | Zhao, Naixuan,et al."Electrochemical Alkoxylation of Benzylic C(sp3)-H Bonds".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2025):6. |
入库方式： OAI收割
来源：上海药物研究所
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