Visible-Light-Induced Acyl and Thiocyano Pyridylation of Alkenes with Aldehyde and NH4SCN
文献类型：期刊论文
| 作者 | Wang, Xu1,2,3; Jiang, Qi-Xuan1,3; Xiao, Bi-Yin1,3; Huang, Wei1,2,3; Zhang, Feng-Hua1,3 |
| 刊名 | ADVANCED SYNTHESIS & CATALYSIS
 |
| 出版日期 | 2025-01-10 |
| 页码 | 8 |
| 关键词 | photoredox catalysis beta-pyridinyl ketones beta-pyridinyl thiocyanates radical anion metal free |
| ISSN号 | 1615-4150 |
| DOI | 10.1002/adsc.202401373 |
| 英文摘要 | beta-pyridinyl ketones and beta-pyridinyl thiocyanates are commonly used as an essential organic synthesis intermediate and widely present in various drug molecules and bioactive molecules. Herein, a photoredox catalyzed acyl and thiocyano pyridylation of alkenes with aldehydes and NH4SCN via HAT and SET strategy respectively is described. This protocol employs more readily accessible aldehydes and NH4SCN as radical precursors under redox-neutral conditions. Moreover, high atom economy, simple and accessible starting materials, late-stage modification and wide substrate scope including primary, secondary alkyl aldehydes and aromatic aldehydes enable the potential application in the organic synthesis. |
| WOS关键词 | RADICAL-POLAR CROSSOVER ; DIFUNCTIONALIZATION ; CHEMISTRY |
| 资助项目 | Zhejiang Provincial Natural Science Foundation of China ; Hangzhou Innovation and Entrepreneurship Leading Team Project[TD2020005] ; National Key Research and Development Program of China[2023YFD1800100] ; Hangzhou Institute for Advanced Study, UCAS[2023HIAS-V006] ; [LQ24B020006] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001393208300001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315624]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Feng-Hua |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 101408, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xu,Jiang, Qi-Xuan,Xiao, Bi-Yin,et al. Visible-Light-Induced Acyl and Thiocyano Pyridylation of Alkenes with Aldehyde and NH4SCN[J]. ADVANCED SYNTHESIS & CATALYSIS,2025:8. |
| APA | Wang, Xu,Jiang, Qi-Xuan,Xiao, Bi-Yin,Huang, Wei,&Zhang, Feng-Hua.(2025).Visible-Light-Induced Acyl and Thiocyano Pyridylation of Alkenes with Aldehyde and NH4SCN.ADVANCED SYNTHESIS & CATALYSIS,8. |
| MLA | Wang, Xu,et al."Visible-Light-Induced Acyl and Thiocyano Pyridylation of Alkenes with Aldehyde and NH4SCN".ADVANCED SYNTHESIS & CATALYSIS (2025):8. |
入库方式： OAI收割
来源：上海药物研究所
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