2-(1-Phenylvinyl)benzoic acid as a highly active leaving group for metal-free glycosylation
文献类型：期刊论文
| 作者 | Dai, Qi1,2,3; Li, Penghua1,3; Cao, Yaran1,2,3; Xie, Xiangying1,2,3; Zhang, Chen1,2,3; Zheng, Mingyue1,2,3 ; Shen, Haiwei1,3
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| 刊名 | ORGANIC CHEMISTRY FRONTIERS
 |
| 出版日期 | 2025-01-06 |
| 页码 | 7 |
| ISSN号 | 2052-4129 |
| DOI | 10.1039/d4qo02186j |
| 英文摘要 | In the field of modern biochemistry and drug development, the acquisition of homogeneous sugar complexes is crucial for evaluating their biophysical activities. These sugar complexes are essential for understanding biomacromolecule functions and serve as potential vaccine candidates. The synthesis of sugar conjugates is a key step in achieving this goal, and the selection of sugar donors and control of glycosylation reaction outcomes are particularly important in this process. Our recent research indicates that glycosyl PVB donors exhibit self-stability, high reactivity, and excellent yields when activated by NIS/TMSOTf promoters. Notably, glycosyl PVB donors can achieve similar glycosylation effects with I2 activation. These metal-free reaction conditions are broadly applicable to the synthesis of various O-glycosides, N-glycosides, and the carbohydrate drug PG545 (an anti-tumor agent). |
| WOS关键词 | CARBOHYDRATE-CHEMISTRY ; O-GLYCOSYLATION ; IODINE ; EFFICIENT ; STRATEGY ; DIMETHYLFORMAMIDE ; ALKYNYLBENZOATES ; OLIGOSACCHARIDE ; ACTIVATION ; IODIDES |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001393352900001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315636]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Penghua; Zheng, Mingyue; Shen, Haiwei |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmacol Sci & Technol, Hangzhou 310024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dai, Qi,Li, Penghua,Cao, Yaran,et al. 2-(1-Phenylvinyl)benzoic acid as a highly active leaving group for metal-free glycosylation[J]. ORGANIC CHEMISTRY FRONTIERS,2025:7. |
| APA | Dai, Qi.,Li, Penghua.,Cao, Yaran.,Xie, Xiangying.,Zhang, Chen.,...&Shen, Haiwei.(2025).2-(1-Phenylvinyl)benzoic acid as a highly active leaving group for metal-free glycosylation.ORGANIC CHEMISTRY FRONTIERS,7. |
| MLA | Dai, Qi,et al."2-(1-Phenylvinyl)benzoic acid as a highly active leaving group for metal-free glycosylation".ORGANIC CHEMISTRY FRONTIERS (2025):7. |
入库方式： OAI收割
来源：上海药物研究所
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