Jatrophane and ingenane diterpenoids with anti-inflammatory activity from Euphorbia esula
文献类型：期刊论文
| 作者 | Li, Yu-Peng2; Li, Ying2; Gao, Wen-Jing2; Fang, Chu-Hong2; Lv, Ming-Jun2; Yue, Jian-Min1,2 ; Yu, Jin-Hai2
|
| 刊名 | PHYTOCHEMISTRY
 |
| 出版日期 | 2025-04-01 |
| 卷号 | 232页码:13 |
| 关键词 | Euphorbia esula L. Euphorbiaceae Diterpenoid Anti-inflammatory NF-kappa B/MAPK Nrf2/HO-1 |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2024.114369 |
| 英文摘要 | A phytochemical investigation into the plants of Euphorbia esula L. has yielded 19 diterpenoids, comprising 17 jatrophane-type (1-7 and 9-18) and two ingenane-type (8 and 19). The structures of these compounds were elucidated by a combination of spectrum elucidations, quantum chemical calculations, and X-ray single crystal diffraction. Biological evaluations demonstrated that compounds 6, 8, 18, and 19 show significant antiinflammatory activity with IC50 values within 10 mu M, without displaying any morphological signs of cytotoxicity. Further biological analysis revealed that euphoresulin A (8) is involved in the suppression of inflammatory response by blocking the activation of NF-kappa B/MAPK and activating Nrf2/HO-1 singling pathways. |
| WOS关键词 | MACROCYCLIC DITERPENE ; KANSUI |
| 资助项目 | Shandong Laboratory Program[SYS202205] ; Key R&D Program of Shandong Province, China[2024CXPT029] ; Natural Science Foundation of Shandong Province[ZR2024QB356] ; Shandong Postdoctoral Science Foundation[SDCX-ZG-202400081] ; Shanghai Postdoctoral Excellence Program[2023701] ; National Natural Science Foundation of China[22237007] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:001393736200001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315660]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min; Yu, Jin-Hai |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China 2.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yu-Peng,Li, Ying,Gao, Wen-Jing,et al. Jatrophane and ingenane diterpenoids with anti-inflammatory activity from Euphorbia esula[J]. PHYTOCHEMISTRY,2025,232:13. |
| APA | Li, Yu-Peng.,Li, Ying.,Gao, Wen-Jing.,Fang, Chu-Hong.,Lv, Ming-Jun.,...&Yu, Jin-Hai.(2025).Jatrophane and ingenane diterpenoids with anti-inflammatory activity from Euphorbia esula.PHYTOCHEMISTRY,232,13. |
| MLA | Li, Yu-Peng,et al."Jatrophane and ingenane diterpenoids with anti-inflammatory activity from Euphorbia esula".PHYTOCHEMISTRY 232(2025):13. |
入库方式： OAI收割
来源：上海药物研究所
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