Zebrafish as a Visible Neuroinflammation Model for Evaluating the Anti-Inflammation Effect of Curcumin-Loaded Ferritin Nanoparticles
文献类型：期刊论文
| 作者 | Chen, Jiamao10; Zha, Haidong10; Xu, Meng10; Li, Shuli10; Han, Yunfeng10; Li, Qinyu2,4; Ge, Wei6,7; Lee, Simon Ming-Yuen5; Gan, Yong1,2,3,4 ; Zheng, Ying8,9,10
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| 刊名 | ACS APPLIED MATERIALS & INTERFACES
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| 出版日期 | 2025-01-10 |
| 卷号 | 17期号:3页码:4450-4462 |
| 关键词 | zebrafish neuroinflammation model ferritin curcumin blood-brain barrier (BBB) drugdelivery |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.4c14809 |
| 英文摘要 | It is crucial to inhibit the neuroinflammation response as it is a prominent factor contributing to the pathogenesis of neurodegenerative disorders. However, the limited development of neuroinflammation models dramatically hinders the efficiency of nanomedicine discovery. In recent years, the optically transparent zebrafish model provided unique advantages for in vivo imaging of the whole body, allowing the progression of the disease to be visualized. In this study, a lipopolysaccharide (LPS)-mediated zebrafish neuroinflammation model was established to visualize the brain distribution and quickly evaluate the anti-inflammation effect of human ferritin-loaded curcumin (Cur@HFn) nanoparticles. The Cur@HFn drug delivery system was successfully prepared and characterized. The HFn nanocage demonstrated significant brain accumulation and prolonged circulation in a zebrafish larval model. In the LPS-induced zebrafish model, Cur@HFn significantly reduced neutrophil recruitment within the brain region of the LPS-treated zebrafish. Additionally, Cur@HFn mitigated nitric oxide (NO) release and downregulated the mRNA expression levels of proinflammatory cytokines, including TNF-alpha and IL-1 beta. Lastly, Cur@HFn significantly reduced the damage of raphe nucleus neurons and alleviated the locomotion deficiency caused by LPS. Overall, our findings highlight that Cur@HFn is a promising drug delivery system for the targeted treatment of brain disorders. This zebrafish neuroinflammation model could be used for high-throughput in vivo drug screening and discovery. |
| WOS关键词 | BLOOD-BRAIN-BARRIER ; H-FERRITIN ; APOFERRITIN ; EFFICACY ; DELIVERY |
| 资助项目 | Universidade de Macau[005/2023/SKL] ; Universidade de Macau[0076/2023/RIB3] ; Macau Science and Technology Development Fund (FDCT)[EF022/ICMS-ZY/2022/SZSTIC] ; Technology and Innovation Commission of Shenzhen Municipality[CP-026-2022] ; Guangdong Institute for Drug Control[MYRG-GRG2023-00159-ICMS-UMDF] ; University of Macau |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001395268000001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315672]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zheng, Ying |
| 作者单位 | 1.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipie, Beijing 100050, Peoples R China 2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.Hong Kong Polytech Univ, Dept Food Sci & Nutr, Hong Kong 999077, Peoples R China 6.Univ Macau, Fac Hlth Sci, Ctr Reprod Dev & Aging CRDA, Taipa 999078, Macao, Peoples R China 7.Univ Macau, Fac Hlth Sci, Dept Biomed Sci, Taipa 999078, Macao, Peoples R China 8.Univ Macau, MoE Frontiers Sci Ctr Precis Oncol, Taipa 999078, Macao, Peoples R China 9.Univ Macau, Fac Hlth Sci, Dept Pharmaceut Sci, Taipa 999078, Macao, Peoples R China 10.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa 999078, Macao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Jiamao,Zha, Haidong,Xu, Meng,et al. Zebrafish as a Visible Neuroinflammation Model for Evaluating the Anti-Inflammation Effect of Curcumin-Loaded Ferritin Nanoparticles[J]. ACS APPLIED MATERIALS & INTERFACES,2025,17(3):4450-4462. |
| APA | Chen, Jiamao.,Zha, Haidong.,Xu, Meng.,Li, Shuli.,Han, Yunfeng.,...&Zheng, Ying.(2025).Zebrafish as a Visible Neuroinflammation Model for Evaluating the Anti-Inflammation Effect of Curcumin-Loaded Ferritin Nanoparticles.ACS APPLIED MATERIALS & INTERFACES,17(3),4450-4462. |
| MLA | Chen, Jiamao,et al."Zebrafish as a Visible Neuroinflammation Model for Evaluating the Anti-Inflammation Effect of Curcumin-Loaded Ferritin Nanoparticles".ACS APPLIED MATERIALS & INTERFACES 17.3(2025):4450-4462. |
入库方式： OAI收割
来源：上海药物研究所
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