Therapeutic potential and pharmacological mechanisms of Traditional Chinese Medicine in gout treatment
文献类型：期刊论文
| 作者 | Guo, Jing-wen2; Lin, Guo-qiang2; Tang, Xin-yi2; Yao, Jia-ying2; Feng, Chen-guo2; Zuo, Jian-ping1 ; He, Shi-jun2
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2025-01-17 |
| 页码 | 21 |
| 关键词 | gout hyperuricemia gouty arthritis Traditional Chinese Medicine TCM formula Chinese herb |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/s41401-024-01459-6 |
| 英文摘要 | Gout is a systemic metabolic disorder caused by elevated uric acid (UA) levels, affecting over 1% of the population. The most common complication of gout is gouty arthritis (GA), characterized by swelling, pain or tenderness in peripheral joints or bursae, which can lead to the formation of tophi. At present, western medicines like colchicine, febuxostat and allopurinol are the primary treatment strategy to alleviate pain and prevent flare-ups in patients with GA, but they have significant side effects and increased mortality risks. Traditional Chinese medicine (TCM) has been utilized for thousands of years for the prevention and treatment of GA, demonstrating effective control over serum UA (SUA) levels with fewer side effects. Herein we summarized a total of 541 studies published from 2000 to 2023 in sources including PubMed, Web of Science, the Cochrane Library and Embase, highlighting the therapeutic potential of TCM in treating gout and GA, particularly in combination with modern medical strategies. This review focuses on TCM formulas, Chinese herbal extracts, and active compounds derived from TCM, providing an overview of recent clinical application and the pharmacological research based on animal models and cellular systems. Particularly, the current review categorized the clinical and experimental evidence into the strategies for improving hyperuricemia, decreasing the sudden onset of acute GA and retarding chronic GA progression, supplied further coherent reference and enlightenment for clinicians, investigators of natural product chemistry, researchers in TCM and pharmacology. We hope this article will inspire the development of novel formulas and molecular entities for the treatment of gout and GA. |
| WOS关键词 | SERUM URIC-ACID ; MS BASED METABOLOMICS ; OXIDATIVE STRESS ; ANIMAL-MODEL ; IN-VITRO ; INDUCED INFLAMMATION ; NLRP3 INFLAMMASOME ; XANTHINE-OXIDASE ; SMILAX-RIPARIA ; DOUBLE-BLIND |
| 资助项目 | State Key Laboratory of Drug Research[SKLDR-2023-KF-02] ; CAS Light of West China Program, CAS Interdisciplinary Innovation Team[xbzg-zdsys-202303] ; Major projects for fundamental research of Yunnan province[202201BC070002] ; Renowned Traditional Chinese Medicine Academic Experience Inheritance, Innovation, Quality Improvement and Upgrading Project from Shanghai Municipal Health Commission/Shanghai Municipal Administration of Traditional Chinese Medicine[A1-C24-800-0302] ; Shanghai Frontiers Science Center for TCM Chemical Biology[WSRWW83639] ; Shanghai Frontiers Science Center for TCM Chemical Biology[TOISUa4a61] ; Shanghai Frontiers Science Center for TCM Chemical Biology[UURWO05a2a] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001399432500001 |
| 出版者 | NATURE PUBL GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315872]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Feng, Chen-guo; Zuo, Jian-ping; He, Shi-jun |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Jing-wen,Lin, Guo-qiang,Tang, Xin-yi,et al. Therapeutic potential and pharmacological mechanisms of Traditional Chinese Medicine in gout treatment[J]. ACTA PHARMACOLOGICA SINICA,2025:21. |
| APA | Guo, Jing-wen.,Lin, Guo-qiang.,Tang, Xin-yi.,Yao, Jia-ying.,Feng, Chen-guo.,...&He, Shi-jun.(2025).Therapeutic potential and pharmacological mechanisms of Traditional Chinese Medicine in gout treatment.ACTA PHARMACOLOGICA SINICA,21. |
| MLA | Guo, Jing-wen,et al."Therapeutic potential and pharmacological mechanisms of Traditional Chinese Medicine in gout treatment".ACTA PHARMACOLOGICA SINICA (2025):21. |
入库方式： OAI收割
来源：上海药物研究所
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