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Synthesis of Unprotected Racemic Tryptophan Derivatives Using Gramine via Nickel(II) Complex

文献类型：期刊论文

作者Chen, Qiangqiang7,8; Li, Yazhou6,7; Xiao, Zhekai5,6; Soloshonok, Vadim A.3,4; Javahershenas, Ramin2; Liu, Hong5,6,7,8; Wang, Jiang1,7
刊名JOURNAL OF ORGANIC CHEMISTRY
出版日期2025-01-17
卷号90期号:4页码:1636-1644
ISSN号0022-3263
DOI10.1021/acs.joc.4c02709
英文摘要A chemical method for the preparation of nonprotected tryptophan via nickel(II) complexes under simple operating conditions was established. The carefully designed nickel(II) glycinates are inexpensive and can be quantitatively recovered releasing the target tryptophans in high yield. The method has a wide range of synthesis generality, allowing the preparation of various substituted tryptophans. Furthermore, the scalability of this method bodes well for its synthetic use as a general approach to biologically interesting tailor-made tryptophans and related compounds.
WOS关键词MICHAEL ADDITION-REACTIONS ; VIRTUALLY COMPLETE CONTROL ; BETA-AMINO ACIDS ; ASYMMETRIC-SYNTHESIS ; ENANTIOSELECTIVE SYNTHESIS ; NUCLEOPHILIC GLYCINE ; KINETIC RESOLUTION ; PYROGLUTAMIC ACIDS ; NI(II) COMPLEX ; ALPHA-AMINO
资助项目National Natural Science Foundation of China[82322063] ; National Natural Science Foundation of China[22177124] ; National Natural Science Foundation of China[82130105] ; National Natural Science Foundation of China[22337003] ; National Natural Science Foundation of China[82121005] ; National Natural Science Foundation of China[LG-GG-202403-01] ; National Natural Science Foundation of China[23XD1460300] ; Program of Shanghai Academic Research Leader
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001399583300001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/315887]  
专题新药研究国家重点实验室
通讯作者Liu, Hong; Wang, Jiang
作者单位1.Lingang Lab, Shanghai 200031, Peoples R China
2.Urmia Univ, Fac Chem, Dept Organ Chem, Orumiyeh 5756151818, Iran
3.Basque Fdn Sci, Ikerbasque, Bilbao 48013, Spain
4.Univ Basque Country UPV EHU, Fac Chem, Dept Organ Chem 1, San Sebastian 20018, Spain
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.UCAS, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
8.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Qiangqiang,Li, Yazhou,Xiao, Zhekai,et al. Synthesis of Unprotected Racemic Tryptophan Derivatives Using Gramine via Nickel(II) Complex[J]. JOURNAL OF ORGANIC CHEMISTRY,2025,90(4):1636-1644.
APA Chen, Qiangqiang.,Li, Yazhou.,Xiao, Zhekai.,Soloshonok, Vadim A..,Javahershenas, Ramin.,...&Wang, Jiang.(2025).Synthesis of Unprotected Racemic Tryptophan Derivatives Using Gramine via Nickel(II) Complex.JOURNAL OF ORGANIC CHEMISTRY,90(4),1636-1644.
MLA Chen, Qiangqiang,et al."Synthesis of Unprotected Racemic Tryptophan Derivatives Using Gramine via Nickel(II) Complex".JOURNAL OF ORGANIC CHEMISTRY 90.4(2025):1636-1644.

入库方式： OAI收割

来源：上海药物研究所

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