Eleutherlenes A-D, Diverse Types of Naphthalene Derivatives with Anti-inflammatory Activity from Eleutherine bulbosa
文献类型：期刊论文
| 作者 | Gao, Yuan2,3; Li, Ying1; Zhou, Jun-Su2; Xie, Zhi-Xiang2; Wu, Pei-Qian2; Mu, Qing3; Zhou, Bin1,2; Yue, Jian-Min1,2,3
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2025-01-20 |
| 卷号 | 27期号:4页码:1066-1071 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.4c04798 |
| 英文摘要 | Eleutherlene A (1), an unprecedented carbon skeleton featuring an aryl-fused 6-methyl-2,7-dioxabicyclo[3.2.1]octane unit, and eleutherlene B (2), a naphthoquinone derivative with interesting ring fusion of an alpha,beta-unsaturated gamma-lactam and a tetrahydropyran moiety, along with two novel naphthoquinone alkaloids, eleutherlenes C (3) and D (4), were isolated from Eleutherine bulbosa and identified. Their structures were elucidated by spectroscopic analyses along with computer-assisted structure elucidation, including ACD/Structure Elucidator and computational calculations and X-ray crystal diffraction. A plausible biosynthetic route for 1 and 2 was proposed. Compound 1 showed significant anti-inflammatory activity with respect to the inhibition of pro-inflammatory mediators NO, IL-1 beta, iNOS, and COX-2. Mechanistically, compound 1 inhibited the inflammatory response by suppressing NF-kappa B/MAPK and activating the Nrf2/Keap1 signaling pathway in LPS-induced RAW 264.7 cells. |
| WOS关键词 | AMERICANA |
| 资助项目 | National Natural Science Foundation of China[22237007] ; National Natural Science Foundation of China[82322064] ; National Natural Science Foundation of China[SIMM0120231002] ; Shanghai Institute of Materia Medica of CAS[2022283] ; Youth Innovation Promotion Association of CAS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001400713500001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315905]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Mu, Qing; Zhou, Bin; Yue, Jian-Min |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Yuan,Li, Ying,Zhou, Jun-Su,et al. Eleutherlenes A-D, Diverse Types of Naphthalene Derivatives with Anti-inflammatory Activity from Eleutherine bulbosa[J]. ORGANIC LETTERS,2025,27(4):1066-1071. |
| APA | Gao, Yuan.,Li, Ying.,Zhou, Jun-Su.,Xie, Zhi-Xiang.,Wu, Pei-Qian.,...&Yue, Jian-Min.(2025).Eleutherlenes A-D, Diverse Types of Naphthalene Derivatives with Anti-inflammatory Activity from Eleutherine bulbosa.ORGANIC LETTERS,27(4),1066-1071. |
| MLA | Gao, Yuan,et al."Eleutherlenes A-D, Diverse Types of Naphthalene Derivatives with Anti-inflammatory Activity from Eleutherine bulbosa".ORGANIC LETTERS 27.4(2025):1066-1071. |
入库方式： OAI收割
来源：上海药物研究所
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