Applications of innovative synthetic strategies in anticancer drug discovery: The driving force of new chemical reactions
文献类型：期刊论文
| 作者 | Wang, Han2,3; Ma, Xiaolong2,3; Sun, Longkang1,2,3; Bi, Tongyu2,3; Yang, Weibo1,2,3
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2025-04-15 |
| 卷号 | 119页码:36 |
| 关键词 | Synthetic methodologies Medicinal chemistry New chemical reactions Anticancer drug discovery |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2025.130096 |
| 英文摘要 | The discovery of novel anticancer agents remains a critical goal in medicinal chemistry, with innovative synthetic methodologies playing a pivotal role in advancing this field. Recent breakthroughs in C-H activation reactions, cyclization reactions, multicomponent reactions, cross-coupling reactions, and photo- and electrocatalytic reactions have enabled the efficient synthesis of new molecular scaffolds exhibiting potent biological activities, including anticancer properties. These methodologies have facilitated the functionalization of natural products, the modification of bioactive molecules, and the generation of entirely new compounds, many of which demonstrate strong antitumor activity. This review summarizes the latest synthetic strategies employed over the past five years for discovering anticancer agents, focusing on their influence on drug design. Additionally, the role of new chemical reactions in expanding chemical space and overcoming challenges, such as drug resistance and selectivity, is highlighted, further emphasizing the importance of discovering novel reactions as a key trend in future drug development. |
| WOS关键词 | H BOND FUNCTIONALIZATION ; LIGHT PHOTOREDOX CATALYSIS ; TUMORAL IMMUNE RESISTANCE ; MULTICOMPONENT REACTIONS ; MEDICINAL CHEMISTRY ; NATURAL-PRODUCTS ; DIRECT DIFLUOROMETHYLATION ; BIOLOGICAL EVALUATION ; COUPLING REACTIONS ; METAL-COMPLEXES |
| 资助项目 | National Natural Science Foundation of China[82373708] ; National Natural Science Foundation of China[22171275] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001400979600001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315920]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yang, Weibo |
| 作者单位 | 1.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Han,Ma, Xiaolong,Sun, Longkang,et al. Applications of innovative synthetic strategies in anticancer drug discovery: The driving force of new chemical reactions[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2025,119:36. |
| APA | Wang, Han,Ma, Xiaolong,Sun, Longkang,Bi, Tongyu,&Yang, Weibo.(2025).Applications of innovative synthetic strategies in anticancer drug discovery: The driving force of new chemical reactions.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,119,36. |
| MLA | Wang, Han,et al."Applications of innovative synthetic strategies in anticancer drug discovery: The driving force of new chemical reactions".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 119(2025):36. |
入库方式： OAI收割
来源：上海药物研究所
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