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Uncommon Diterpenoids with Diverse Frameworks from the South China Sea Sponge Spongia officinalis and Their Anti-inflammatory Activities

文献类型：期刊论文

作者Li, Song-Wei4; Liu, Jiao3; Liu, Zi-Yi3; Fu, Yan3; Yao, Li-Gong3; Gu, Yu-Cheng2; Zhang, Hai-Yan3; Li, Xu-Wen1,3; Guo, Yue-Wei1,4
刊名JOURNAL OF ORGANIC CHEMISTRY
出版日期2025-01-24
卷号90期号:5页码:1950-1956
ISSN号0022-3263
DOI10.1021/acs.joc.4c02689
英文摘要Uncommon diterpenoids with diverse frameworks, including one unexpected iodinated oxa-6/6/6/6-tetracyclic diterpene (1) and its monobrominated 6/6/6-tricyclic analogue (2) and one novel isodolastane-type diterpene featuring an unusual aromatic 5/7/6-tricyclic ring system (3) as well as a related known dolastane-type diterpenoid (4), were isolated from the South China Sea sponge Spongia officinalis. Their structures, including absolute configurations, were established by extensive spectroscopic data analysis, X-ray diffraction analysis, and quantum mechanical-nuclear magnetic resonance and time-dependent density functional theory/electronic circular dichroism calculations. A plausible biosynthetic pathway of new compounds 1-3 was proposed. In bioassays, compounds 2 and 4 were found to exhibit significant anti-inflammatory effects on lipopolysaccharide-induced inflammation in BV-2 microglial cells.
资助项目National Natural Science Foundation of China[2022YFC2804100] ; National Natural Science Foundation of China[2021YFF0502400] ; National Key Research and Development Program of China[81991521] ; National Key Research and Development Program of China[82304375] ; National Natural Science Foundation of China[SYS202205] ; Shandong Laboratory Program ; Syngenta-SIMM-PhD Studentship Project
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001406684300001
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/315956]  
专题新药研究国家重点实验室
通讯作者Zhang, Hai-Yan; Li, Xu-Wen; Guo, Yue-Wei
作者单位1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China
2.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Shanghai Univ, Sch Med, Shanghai 200444, Peoples R China
推荐引用方式
GB/T 7714		 Li, Song-Wei,Liu, Jiao,Liu, Zi-Yi,et al. Uncommon Diterpenoids with Diverse Frameworks from the South China Sea Sponge Spongia officinalis and Their Anti-inflammatory Activities[J]. JOURNAL OF ORGANIC CHEMISTRY,2025,90(5):1950-1956.
APA Li, Song-Wei.,Liu, Jiao.,Liu, Zi-Yi.,Fu, Yan.,Yao, Li-Gong.,...&Guo, Yue-Wei.(2025).Uncommon Diterpenoids with Diverse Frameworks from the South China Sea Sponge Spongia officinalis and Their Anti-inflammatory Activities.JOURNAL OF ORGANIC CHEMISTRY,90(5),1950-1956.
MLA Li, Song-Wei,et al."Uncommon Diterpenoids with Diverse Frameworks from the South China Sea Sponge Spongia officinalis and Their Anti-inflammatory Activities".JOURNAL OF ORGANIC CHEMISTRY 90.5(2025):1950-1956.

入库方式： OAI收割

来源：上海药物研究所

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