Aggregation-Mediated Photoacoustic/NIR-II and Photodynamic Properties of pH-Reversible Thiopyrylium Agents: A Computational and Experimental Approach
文献类型：期刊论文
| 作者 | Liu, Yishen11,12,13; Zhang, Zhiyun11,12,13; Hou, Xiaowen11,12,13; Ding, Qihang9,10,13; Zeng, Silue7,8; Shen, Hanchen5,6; Gong, Wanxia13; Ding, Taotao11,12,13; Mahmood, Zafar4; Zeng, Xiaodong11,12 |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2025-02-03 |
| 页码 | 11 |
| 关键词 | aggregation near-infrared II imaging pH response photoacoustic imaging photodynamic therapy |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.202420006 |
| 英文摘要 | Aggregation profoundly influences the photophysical properties of molecules. Here, a new series of thiopyrylium-based hemicyanine near-infrared II (NIR-II) fluorophores is developed by meticulously adjusting their aggregation states. Notably, the star molecule HTPA exhibits a remarkable pH-responsive behavior and a significant increase in photoacoustic (PA) intensity when aggregated. Additionally, their behavior and pH reversibility during aggregation formation are systematically investigated, including computational optimization, femtosecond transient absorption spectroscopy, NMR analysis, and single crystal analysis. Finally, an innovative "off " nanoparticle specifically is designed for effective tumor-targeted PA/NIR-II dual-modal imaging and photodynamic therapy by utilizing a pH-responsive polymer. The signal-to-background ratio (SBR) of PA signals significantly increased to 169 in the region of interest (ROI) in the mouse model when irradiated at 1064 nm. These findings not only provide a promising avenue for future studies of NIR-II small molecules but also pave the way for significant advances in the field of integrated cancer diagnosis and therapy. |
| WOS关键词 | EMISSION |
| 资助项目 | National Key R&D Program of China ; National Natural Science Foundation of China[22477129] ; National Natural Science Foundation of China[82273796] ; National Natural Science Foundation of China[82372005] ; National Natural Science Foundation of China[82171986] ; Shenzhen Science and Technology Research Grant[JCYJ20240813111300001] ; Shenzhen Science and Technology Research Grant[JCYJ20220530140605012] ; Shenzhen Science and Technology Research Grant[JCYJ20230807090100002] ; Guangdong Basic and Applied Basic Research Foundation[2023A1515012649] ; Taishan Scholar Project of Shandong Province[TSQN202306320] ; Tibet Autonomous Region Science and Technology Plan Project Key Project[XZ202301ZY0014G] ; Tibet Autonomous Region Science and Technology Plan Project Key Project[LSKJ202445] ; Natural Science Foundation of Shandong Province[ZR2023MB085] ; Shandong Laboratory Program[SYS202205] ; [2023YFC3605502] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001411194800001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315968]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Xiao, Yuling |
| 作者单位 | 1.Nankai Univ, Frontiers Sci Ctr Cell Responses, State Key Lab Med Chem Biol, Key Lab Bioact Mat,Minist Educ,Coll Life Sci, Tianjin 300071, Peoples R China 2.Northwestern Polytech Univ, Xian Inst Flexible Elect IFE, Xian 710072, Peoples R China 3.Northwestern Polytech Univ, Frontiers Sci Ctr Flexible Elect, Xian 710072, Peoples R China 4.Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Peoples R China 5.Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Hong Kong 999077, Peoples R China 6.Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recons, Dept Chem, Hong Kong Branch, Hong Kong 999077, Peoples R China 7.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg 1, Guangzhou 510280, Peoples R China 8.Chinese Acad Sci, Shenzhen Inst Adv Technol, Res Ctr Biomed Opt & Mol Imaging, Key Lab Biomed Imaging Sci & Syst, Shenzhen 518055, Peoples R China 9.Korea Univ, Dept Chem, Seoul 02841, South Korea 10.Wuhan Univ, Shenzhen Inst, Shenzhen 518057, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Yishen,Zhang, Zhiyun,Hou, Xiaowen,et al. Aggregation-Mediated Photoacoustic/NIR-II and Photodynamic Properties of pH-Reversible Thiopyrylium Agents: A Computational and Experimental Approach[J]. ADVANCED MATERIALS,2025:11. |
| APA | Liu, Yishen.,Zhang, Zhiyun.,Hou, Xiaowen.,Ding, Qihang.,Zeng, Silue.,...&Xiao, Yuling.(2025).Aggregation-Mediated Photoacoustic/NIR-II and Photodynamic Properties of pH-Reversible Thiopyrylium Agents: A Computational and Experimental Approach.ADVANCED MATERIALS,11. |
| MLA | Liu, Yishen,et al."Aggregation-Mediated Photoacoustic/NIR-II and Photodynamic Properties of pH-Reversible Thiopyrylium Agents: A Computational and Experimental Approach".ADVANCED MATERIALS (2025):11. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。