N-Benzyl-r-2,c-6-diphenylpiperidines: Synthesis, spectral characterization, conformational analysis and evaluation of biological activities
文献类型：期刊论文
| 作者 | Chandrika, P.4; Sethuvasan, S.3; Santhosh, P.2; Kesavan, M.1; Aswathy, K. A.1; Ganesh, M. R.1; Ponnuswamy, S.4 |
| 刊名 | JOURNAL OF MOLECULAR STRUCTURE
 |
| 出版日期 | 2025-05-05 |
| 卷号 | 1329页码:13 |
| 关键词 | N -benzyl-2,6-diphenylpiperidines NMR spectra Anticancer activity Antioxidant activity Antimicrobial activity Antimicrobial activity |
| ISSN号 | 0022-2860 |
| DOI | 10.1016/j.molstruc.2025.141376 |
| 英文摘要 | Six new N-benzyl-2,6-diphenylpiperidines 13-18 have been synthesized. The newly synthesized compounds are characterized using mass, IR, 1D NMR and selected compounds are characterized by 2D (H-1-H-1 COSY and H-1-C-13 HSQC) NMR spectra. In the IR spectra of compounds 13-18, the disappearance of a N-H stretching frequency around 3300 cm(-1) confirms the N-benzylation of piperidines 7-12. The NMR spectral data suggest that the compounds 13-18 exhibit a preference for chair conformation. Invitro anti-bacterial evaluation reveals that when compared to standard drug gatifloxacin, the compounds 14, 17 & 18 show greater efficacy against all the four tested bacteria and these compounds may act as highly effective drugs. All the compounds show less activity against the tested fungi. Compounds 13, 16 & 18 show the strongest radical scavenging activity out of the six new compounds against DPPH. Against the human leukemic THP-1 cell line, compounds 13, 16 & 18 exhibit the highest cytotoxicity in MTT assay. The ROS scavenging activity was determined for the compounds 13, 16 & 18 and the order of ROS scavenging efficiency is 18 > 16 > 13. Based on the biological evaluation, compound 18 can be utilized as a promising drug candidate against pathogenic bacterial infection and cancer treatment. |
| WOS关键词 | IN-VITRO ; STEREOCHEMISTRY ; CANCER ; MANAGEMENT |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001406074800001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315983]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Ponnuswamy, S. |
| 作者单位 | 1.SRM Inst Sci & Technol, Interdisciplinary Inst Indian Syst Med, Chennai 603203, Tamil Nadu, India 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 3.Venkatasai Life Sci, 5-5-35-207B, Hyderabad 500072, India 4.Govt Arts Coll Autonomous, PG & Res Dept Chem, Coimbatore 641018, Tamil Nadu, India |
| 推荐引用方式 GB/T 7714 | Chandrika, P.,Sethuvasan, S.,Santhosh, P.,et al. N-Benzyl-r-2,c-6-diphenylpiperidines: Synthesis, spectral characterization, conformational analysis and evaluation of biological activities[J]. JOURNAL OF MOLECULAR STRUCTURE,2025,1329:13. |
| APA | Chandrika, P..,Sethuvasan, S..,Santhosh, P..,Kesavan, M..,Aswathy, K. A..,...&Ponnuswamy, S..(2025).N-Benzyl-r-2,c-6-diphenylpiperidines: Synthesis, spectral characterization, conformational analysis and evaluation of biological activities.JOURNAL OF MOLECULAR STRUCTURE,1329,13. |
| MLA | Chandrika, P.,et al."N-Benzyl-r-2,c-6-diphenylpiperidines: Synthesis, spectral characterization, conformational analysis and evaluation of biological activities".JOURNAL OF MOLECULAR STRUCTURE 1329(2025):13. |
入库方式： OAI收割
来源：上海药物研究所
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