Recent Development of Small Molecule Drugs for the Treatment of Osteoarthritis
文献类型：期刊论文
| 作者 | Zhang, Xiaofei; Yang, Chunhao
|
| 刊名 | PROGRESS IN CHEMISTRY
 |
| 出版日期 | 2024-12-24 |
| 卷号 | 36期号:12页码:1849-1858 |
| 关键词 | osteoarthritis small molecule drugs drug development |
| ISSN号 | 1005-281X |
| DOI | 10.7536/PC241115 |
| 英文摘要 | Osteoarthritis is a common degenerative disease in middle-aged and elderly people, and its lesions involve the entire joint, such as cartilage, subchondral bone and synovial membrane. Although there are some launched drugs that can be used to relieve the pain caused by osteoarthritis, the therapeutic effects are insufficient and there are some certain side effects. For now, except for artificial joint replacement for late stage of osteoarthritis, there are no effective drugs for early and middle stage of osteoarthritis to delay its progression. The treatment of osteoarthritis in clinical faces a huge demand for valid drugs, but the development of therapeutic drugs is way behind schedule. This review focuses on the progress of small molecule drugs for the treatment of osteoarthritis, especially the small molecule chemical entities which have entered the clinical trial stage. We hope this article will provide inspiration for the researchers on the drug development of osteoarthritis. |
| WOS关键词 | WNT PATHWAY INHIBITOR ; BIOLOGICAL EVALUATION ; GLUCOSAMINE SULFATE ; CARTILAGE ; PROGRESSION ; DISEASE ; POTENT ; SM04690 ; TARGETS ; AGENTS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001408967300003 |
| 出版者 | CHINESE ACAD SCIENCES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/315986]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yang, Chunhao |
| 作者单位 | Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaofei,Yang, Chunhao. Recent Development of Small Molecule Drugs for the Treatment of Osteoarthritis[J]. PROGRESS IN CHEMISTRY,2024,36(12):1849-1858. |
| APA | Zhang, Xiaofei,&Yang, Chunhao.(2024).Recent Development of Small Molecule Drugs for the Treatment of Osteoarthritis.PROGRESS IN CHEMISTRY,36(12),1849-1858. |
| MLA | Zhang, Xiaofei,et al."Recent Development of Small Molecule Drugs for the Treatment of Osteoarthritis".PROGRESS IN CHEMISTRY 36.12(2024):1849-1858. |
入库方式： OAI收割
来源：上海药物研究所
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