Harnessing Functional Food Sources: Deriving Anti-Inflammatory and Antibacterial Naphthalene Derivatives from the Edible Bulbs of Eleutherine bulbosa
文献类型：期刊论文
| 作者 | Gao, Yuan2,3; Li, Ying1; Zhou, Jun-Su2; Zhao, Peng2; Wu, Pei-Qian2; Mu, Qing3; Yue, Jian-Min1,2,3 ; Zhou, Bin1,2
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| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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| 出版日期 | 2025-02-11 |
| 卷号 | 73期号:7页码:4126-4136 |
| 关键词 | |
| ISSN号 | 0021-8561 |
| DOI | 10.1021/acs.jafc.4c12108 |
| 英文摘要 | The red bulbs of Eleutherine bulbosa, commonly used as a daily dietary ingredient in cooking, are well-known for their rich nutritional profile and potential medicinal properties. This study focused on identifying bioactive components from E. bulbosa by a bioactivity-guided approach combined with global natural products' social molecular networking, which led to the characterization of 12 new naphthalene derivatives, eleuthalenes A-L (1-12), and 22 known analogues. The structures of these compounds were determined through spectroscopic data, X-ray crystallography, and quantum chemical calculations. The anti-inflammatory and antibacterial activities of these compounds were evaluated, with some demonstrating significant anti-inflammatory and moderate antibacterial activities. Further studies revealed that the most potent compound 5 displayed an anti-inflammatory effect in LPS-induced RAW 264.7 cells by suppressing the NF-kappa B/MAPK and activating Nrf2/Keap1 signaling pathways. The results suggested that bioactive naphthalene derivatives are the major pharmacodynamic substances of E. bulbosa. |
| WOS关键词 | AMERICANA ; ANTHRAQUINONES ; NAPHTHOQUINONE |
| 资助项目 | National Natural Science Foundation of China[82322064] ; National Natural Science Foundation of China[82293685] ; National Natural Science Foundation of China[24QA2711300] ; Shanghai Rising-Star Program[2022283] ; Youth Innovation Promotion Association of CAS |
| WOS研究方向 | Agriculture ; Chemistry ; Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:001418189900001 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316203]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Mu, Qing; Yue, Jian-Min; Zhou, Bin |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Yuan,Li, Ying,Zhou, Jun-Su,et al. Harnessing Functional Food Sources: Deriving Anti-Inflammatory and Antibacterial Naphthalene Derivatives from the Edible Bulbs of Eleutherine bulbosa[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2025,73(7):4126-4136. |
| APA | Gao, Yuan.,Li, Ying.,Zhou, Jun-Su.,Zhao, Peng.,Wu, Pei-Qian.,...&Zhou, Bin.(2025).Harnessing Functional Food Sources: Deriving Anti-Inflammatory and Antibacterial Naphthalene Derivatives from the Edible Bulbs of Eleutherine bulbosa.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,73(7),4126-4136. |
| MLA | Gao, Yuan,et al."Harnessing Functional Food Sources: Deriving Anti-Inflammatory and Antibacterial Naphthalene Derivatives from the Edible Bulbs of Eleutherine bulbosa".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 73.7(2025):4126-4136. |
入库方式： OAI收割
来源：上海药物研究所
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