Cryo-Shocked Tumor-Reprogrammed Sonosensitive Antigen-Presenting Cells Improving Sonoimmunotherapy via T Cells and NK Cells Immunity
文献类型：期刊论文
| 作者 | Qian, Xindi4,5,6,7,8; Yi, Wenzhe3,5,6; Yan, Wenlu3,5,6; Cai, Ying2,3,5,6; Hu, Shuangshuang5,6; Yan, Dan5,6; Zhao, Zhiwen3,5,6; Li, Rongzhang3,5,6; Wang, Liying7,8; Xu, Huixiong4 |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2025-02-16 |
| 页码 | 17 |
| 关键词 | adaptive immunity antigen presentation innate immunity sonoimmunotherapy tumor cell reprogramming |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.202413289 |
| 英文摘要 | Ultrasound therapy has turned up as a noninvasive multifunctional tool for cancer immunotherapy. However, the insufficient co-stimulating molecules and loss of peptide-major histocompatibility complex I (MHC-I) expression on tumor cells lead to poor therapy of sonoimmunotherapies. Herein, this work develops a sonosensitive system to augment MHC-I unrestricted natural killer (NK) cell-mediated innate immunity and T cell-mediated adaptive immunity by leveraging antigen presentation cell (APC)-like tumor cells. Genetically engineered tumor cells featuring sufficient co-stimulating molecules are cryo-shocked and conjugated with a sonosensitizer, hematoporphyrin monomethyl ether, using click chemistry. These cells (DPNLs) exhibit characteristics of tumor and draining lymph node homing. Under ultrasound, NK cell-mediated innate immunity within the tumor microenvironment could be activated, and T cells in the tumor-draining lymph nodes (TDLNs) are stimulated through co-stimulatory molecules. In combination with programmed cell death ligand 1 (PD-L1) antibody, DPNLs extend the survival time and inhibited lung metastasis in triple-negative breast cancer (TNBC) models. This study provides an alternative approach for sonoimmunotherapy with precise sonosensitizer delivery and enhanced NK cell and T cell activation. |
| WOS关键词 | PD-L1 EXPRESSION ; CANCER ; DEATH ; CCR5 |
| 资助项目 | National Natural Science Foundation of China ; National Key Research and Development Program of China[2023YFC2414204] ; Shanghai Sailing Program[24YF2755700] ; [81903548] ; [32170935] ; [32070927] ; [81690265] ; [81927801] ; [82151318] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:001421820200001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316218]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Liying; Xu, Huixiong; Li, Yaping |
| 作者单位 | 1.Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264000, Peoples R China 2.Yantai Inst Mat Med Shandong, Yantai Key Lab Nanomed & Adv Preparat, Shanghai 264000, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Fudan Univ, Zhongshan Hosp, Inst Ultrasound Med & Engn, Dept Ultrasound, Shanghai 200032, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 7.Tongji Univ, Shanghai Peoples Hosp 10, Ultrasound Res & Educ Inst, Ctr Minimally Invas Treatment Tumor,Sch Med, Shanghai 200072, Peoples R China 8.Tongji Univ, Shanghai Peoples Hosp 10, Ultrasound Res & Educ Inst, Sch Med,Dept Med Ultrasound, Shanghai 200072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Qian, Xindi,Yi, Wenzhe,Yan, Wenlu,et al. Cryo-Shocked Tumor-Reprogrammed Sonosensitive Antigen-Presenting Cells Improving Sonoimmunotherapy via T Cells and NK Cells Immunity[J]. ADVANCED MATERIALS,2025:17. |
| APA | Qian, Xindi.,Yi, Wenzhe.,Yan, Wenlu.,Cai, Ying.,Hu, Shuangshuang.,...&Li, Yaping.(2025).Cryo-Shocked Tumor-Reprogrammed Sonosensitive Antigen-Presenting Cells Improving Sonoimmunotherapy via T Cells and NK Cells Immunity.ADVANCED MATERIALS,17. |
| MLA | Qian, Xindi,et al."Cryo-Shocked Tumor-Reprogrammed Sonosensitive Antigen-Presenting Cells Improving Sonoimmunotherapy via T Cells and NK Cells Immunity".ADVANCED MATERIALS (2025):17. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。