BMAL1/PGC1a4-FNDC5/irisin axis impacts distinct outcomes of time-of-day resistance exercise
文献类型：期刊论文
| 作者 | Guo, Mingwei9,10; Shen, Fei7,8; Guo, Xiaozhen6; Zhang, Jun9,10; Ma, Ying9,10; Wu, Xia9,10; Zuo, Hui9,10; Yao, Jing9,10; Hu, Yepeng5; Wang, Dongmei9,10 |
| 刊名 | JOURNAL OF SPORT AND HEALTH SCIENCE
 |
| 出版日期 | 2025-12-01 |
| 卷号 | 14页码:23 |
| 关键词 | Daily variance Circadian Muscle strength Metabolic benefits Resistance exercise |
| ISSN号 | 2095-2546 |
| DOI | 10.1016/j.jshs.2024.100968 |
| 英文摘要 | Background: Resistance exercise leads to improved muscle function and metabolic homeostasis. Yet how circadian rhythm impacts exercise outcomes and its molecular transduction remains elusive. Methods: Human volunteers were subjected to 4 weeks of resistance training protocols at different times of day to assess training outcomes and their associations with myokine irisin. Based on rhythmicity of Fibronectin type III domain containing 5 (FNDC5/irisin), we trained wild type and FNDC5 knockout mice at late active phase (high FNDC5/irisin level) or late rest phase (low FNDC5/irisin level) to analyze exercise benefits on muscle function and metabolic homeostasis. Molecular analysis was performed to understand the regulatory mechanisms of FNDC5 rhythmicity and downstream signaling transduction in skeletal muscle. Results: In this study, we showed that regular resistance exercises performed at different times of day resulted in distinct training outcomes in humans, including exercise benefits and altered plasma metabolomics. We found that muscle FNDC5/irisin levels exhibit rhythmicity. Consistent with human data, compared to late rest phase (low irisin level), mice trained chronically at late active phase (high irisin level) gained more muscle capacity along with improved metabolic fitness and metabolomics/lipidomics profiles under a high-fat diet, whereas these differences were lost in FNDC5 knockout mice. Mechanistically, Basic helix-loop-helix ARNT like 1 (BMAL1) and Peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 4 (PGC1a4) induce FNDC5/irisin transcription and rhythmicity, and the signaling is transduced via aV integrin in muscle. Conclusion: Together, our results offered novel insights that exercise performed at distinct times of day determines training outcomes and metabolic benefits through the rhythmic regulation of the BMAL1/PGC1a4-FNDC5/irisin axis. |
| WOS关键词 | SKELETAL-MUSCLE ; MYOKINE IRISIN ; E-BOX ; STRENGTH ; CLOCK ; HYPERTROPHY ; ADAPTATIONS ; TRANSCRIPTION ; DYSFUNCTION ; METABOLISM |
| 资助项目 | National Key Research and Development Program of China[2019YFA0904500] ; National Key Research and Development Program of China[2023YFA1800400] ; National Key Research and Development Program of China[2018YFE0113500] ; National Natural Science Foundation of China[82301777] ; National Natural Science Foundation of China[32222024] ; National Natural Science Foundation of China[32325024] ; National Natural Science Foundation of China[32071148] ; National Natural Science Foundation of China[91957116] ; Fundamental Research Funds for the Central Universities, Science and Technology Commission of Shanghai Municipality[21140904300] ; Fundamental Research Funds for the Central Universities, Science and Technology Commission of Shanghai Municipality[22ZR1421200] ; Innovation Program of Shanghai Municipal Education Commission[2017-01-07-00-09-E00042] ; Key Project of 2022 Higher Education Scientific Research Planning Project of China Association of Higher Education[22TY0218] ; Youth Fund for Humanities and Social Sciences Research of the Ministry of Education[22YJC890023] ; Postdoctoral Fellowship Program of CPSF[GZB20230219] ; China Postdoctoral Science Foundation[2023M741183] ; ECNU public platform for Innovation[011] |
| WOS研究方向 | Social Sciences - Other Topics ; Sport Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:001420850000001 |
| 出版者 | SHANGHAI UNIV SPORT |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316245]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Lu, Jian; Xie, Cen; Xiao, Junjie; Xu, Lingyan |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Ruijin Hosp, China Natl Res Ctr Metab Dis, Sch Med,Dept Endocrinol & Metab, Shanghai 200025, Peoples R China 2.Soochow Univ, Cambridge Suda Genom Resource Ctr, Med Coll, Suzhou 215123, Peoples R China 3.China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 211198, Peoples R China 4.Shanghai Univ, Inst Cardiovasc Sci, Sch Life Sci, Cardiac Regenerat & Ageing Lab, Shanghai 200444, Peoples R China 5.Wenzhou Med Univ, Affiliated Hosp 1, Dept Endocrine & Metab Dis, Wenzhou 325000, Peoples R China 6.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 7.Jiangsu Normal Univ, Inst Phys Educ, Xuzhou 221116, Peoples R China 8.East China Normal Univ, Coll Phys Educ & Hlth, Minist Educ, Key Lab Adolescent Hlth Assessment & Exercise Inte, Shanghai 200241, Peoples R China 9.East China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China 10.East China Normal Univ, Inst Biomed Sci, Shanghai Key Lab Regulatory Biol, Shanghai 200241, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Mingwei,Shen, Fei,Guo, Xiaozhen,et al. BMAL1/PGC1a4-FNDC5/irisin axis impacts distinct outcomes of time-of-day resistance exercise[J]. JOURNAL OF SPORT AND HEALTH SCIENCE,2025,14:23. |
| APA | Guo, Mingwei.,Shen, Fei.,Guo, Xiaozhen.,Zhang, Jun.,Ma, Ying.,...&Xu, Lingyan.(2025).BMAL1/PGC1a4-FNDC5/irisin axis impacts distinct outcomes of time-of-day resistance exercise.JOURNAL OF SPORT AND HEALTH SCIENCE,14,23. |
| MLA | Guo, Mingwei,et al."BMAL1/PGC1a4-FNDC5/irisin axis impacts distinct outcomes of time-of-day resistance exercise".JOURNAL OF SPORT AND HEALTH SCIENCE 14(2025):23. |
入库方式： OAI收割
来源：上海药物研究所
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