The interaction between central and peripheral immune systems in methamphetamine use disorder: current status and future directions
文献类型：期刊论文
| 作者 | Shi, Sai6; Sun, Yiwen6; Zan, Guiying4,5; Zhao, Min1,2,3,6 |
| 刊名 | JOURNAL OF NEUROINFLAMMATION
 |
| 出版日期 | 2025-02-15 |
| 卷号 | 22期号:1页码:14 |
| 关键词 | Methamphetamine Immune system Neuroinflammation Substance use disorder |
| DOI | 10.1186/s12974-025-03372-z |
| 英文摘要 | Methamphetamine (METH) use disorder (MUD) is characterized by compulsive drug-seeking behavior and substantial neurotoxicity, posing a considerable burden on individuals and society. Traditionally perceived as a localized central nervous system disorder, recent preclinical and clinical studies have elucidated that MUD is a multifaceted disorder influenced by various biological systems, particularly the immune system. Emerging evidence suggests that both central and peripheral immune responses play a crucial role in the initiation and persistence of MUD. Conceptualizing it as a systemic immune process prompts significant inquiries regarding the mechanisms of communication between peripheral and central compartments. Also, whether this intercommunication could serve as diagnostic biomarkers or therapeutic targets. This review begins by offering an overview of mechanistic studies pertaining to the neuroimmune and peripheral immune systems. Finally, future directions are suggested through the integration of innovative technologies and multidimensional data to promote the translation of basic mechanistic research into clinical diagnostic and therapeutic interventions. |
| WOS关键词 | BLOOD-BRAIN-BARRIER ; CYTOKINE PRODUCTION ; MICROGLIA ; MONOCYTES ; DAMAGE ; GUT ; IMMUNOMODULATION ; INFLAMMATION ; MACROPHAGES ; EXPRESSION |
| 资助项目 | National Nature Science Foundation ; [2021ZD0202105] ; [2022ZD0211100] ; [82130041] ; [82171484] |
| WOS研究方向 | Immunology ; Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:001421629300002 |
| 出版者 | BMC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316257]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhao, Min |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, 600 South Wan Ping Rd, Shanghai 200030, Peoples R China 2.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techno, Shanghai, Peoples R China 3.Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 5.Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 6.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Sai,Sun, Yiwen,Zan, Guiying,et al. The interaction between central and peripheral immune systems in methamphetamine use disorder: current status and future directions[J]. JOURNAL OF NEUROINFLAMMATION,2025,22(1):14. |
| APA | Shi, Sai,Sun, Yiwen,Zan, Guiying,&Zhao, Min.(2025).The interaction between central and peripheral immune systems in methamphetamine use disorder: current status and future directions.JOURNAL OF NEUROINFLAMMATION,22(1),14. |
| MLA | Shi, Sai,et al."The interaction between central and peripheral immune systems in methamphetamine use disorder: current status and future directions".JOURNAL OF NEUROINFLAMMATION 22.1(2025):14. |
入库方式： OAI收割
来源：上海药物研究所
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