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Synthesis, photophysical properties and fluorescent application of novel [1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one derivatives

文献类型：期刊论文

作者Gan, Suya4; Gao, Li-Xin3,4; Cao, Zitong2,3; Zhang, Chun4; Fu, Yiqiu1; Wang, Wen-Long4
刊名JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
出版日期2025-07-01
卷号464页码:11
关键词[1 4]triazolo[1 5-a]pyrimidin-7(4H)-one derivatives Fluorescence properties Fe 3+ions
ISSN号1010-6030
DOI10.1016/j.jphotochem.2025.116294
英文摘要To extend the application of our theoretical screening method for exploring novel fluorescent fragments, we identified [1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one as a potential fluorophore, whose optical properties are rarely investigated. In this work, nineteen of novel [1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one derivatives were designed, synthesized and the relationship between the structure and fluorescence property of [1,2,4]triazolo [1,5-a]pyrimidin-7(4H)-one derivatives was systematically elucidated. The representative compound 5b exhibited notable fluorescence intensity with good fluorescence quantum yield (Phi = 0.285) in PBS. More importantly, compound 5b selectively detected the Fe3+ ions through fluorescent quenching effect with rapid response, good anti-interference and low detection limit (LOD = 1.82 mu M), and could be applied for encryption ink. This work provides an efficient way to explore novel fluorescent molecules.
WOS关键词OPTICAL-PROPERTIES ; HIGH-PERFORMANCE ; SENSOR ; SUBSTITUENT ; EFFICIENT ; CATALYST ; PROBE
资助项目National Natural Science Foundation of China[22277043] ; Natural Science Foundation of Jiangsu Province[BK20241605] ; High-Level Personnel Project of Jiangsu Province[JSSCBS20210848]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:001424769500001
出版者ELSEVIER SCIENCE SA
源URL[http://119.78.100.183/handle/2S10ELR8/316266]  
专题新药研究国家重点实验室
通讯作者Wang, Wen-Long
作者单位1.Beijing Chemp Biotechnol Co Ltd, Beijing, Peoples R China
2.China Pharmaceut Univ, Inst Pharmaceut Sci, Nanjing 210009, Jiangsu, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Jiangnan Univ, Sch Life Sci & Hlth Engn, Wuxi 214122, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714		 Gan, Suya,Gao, Li-Xin,Cao, Zitong,et al. Synthesis, photophysical properties and fluorescent application of novel [1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one derivatives[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY,2025,464:11.
APA Gan, Suya,Gao, Li-Xin,Cao, Zitong,Zhang, Chun,Fu, Yiqiu,&Wang, Wen-Long.(2025).Synthesis, photophysical properties and fluorescent application of novel [1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one derivatives.JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY,464,11.
MLA Gan, Suya,et al."Synthesis, photophysical properties and fluorescent application of novel [1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one derivatives".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY 464(2025):11.

入库方式： OAI收割

来源：上海药物研究所

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