A comprehensive characterization biotransformation of chlorinated paraffin by human and carp liver microsomes via liquid chromatography-high-resolution mass spectrometry and screening algorithm
文献类型：期刊论文
| 作者 | Chen, Liujun3,4,5; Tang, Caiming2; Yu, Zhiqiang4,5; Zeng, Yanhong1,4,5; Mai, Bixian1,4,5; Luo, Xiaojun1,4,5
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| 刊名 | ENVIRONMENT INTERNATIONAL
 |
| 出版日期 | 2025 |
| 卷号 | 195页码:11 |
| 关键词 | Chlorinated Paraffins Biotransformation Liver microsomes Metabolites Toxicity assessment |
| ISSN号 | 0160-4120 |
| DOI | 10.1016/j.envint.2024.109235 |
| 英文摘要 | The chlorinated paraffin (CP) monomer 1,2,5,6,9,10-Hexachlorodecane (CP-4) was subjected to in vitro biotransformation using human and carp liver microsomes. Five types of CP-4 metabolites (OH-, keto-, enol-, aldehyde- and carboxy-CP-4) were identified in human liver microsomer while only mono-OH-CP-4 was found in the carp liver microsomes. Kinetic studies revealed that the formation of mono-, di-, tri-hydroxylated CP-4, keto-, enol-, and aldehyde-CP-4 in human liver microsomes was best described by substrate inhibition models, whereas the formation of carboxylated CP-4 metabolites best fit the Michaelis-Menten model. Notably, keto-CP-4, enolCP-4 and aldehyde-CP-4 were the predominant metabolites. The estimated Vmax values for these metabolites were significantly higher in the human liver microsomes than in the carp liver microsomes. The intrinsic hepatic clearance (CLint) of CP-4 was higher in humans than in carp, indicating species-specific differences in its metabolism. This study also highlighted potential toxicity concerns, with computational predictions showing varying degrees of acute oral toxicity for CP-4 and its metabolites. These findings indicate significant speciesspecific differences in the biotransformation of CP-4, emphasizing the potential health and environmental risks associated with chlorinated paraffins and their metabolites, and underscore the need for further research to address these concerns. |
| WOS研究方向 | Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001399903900001 |
| 源URL | [http://ir.gig.ac.cn/handle/344008/82558]  |
| 专题 | 有机地球化学国家重点实验室 |
| 通讯作者 | Luo, Xiaojun |
| 作者单位 | 1.Chinese Acad Sci, Guangzhou Inst Geochem, Guangdong Hong Kong MacaoChina Joint Lab Environm, Guangzhou 510640, Peoples R China 2.Dongguan Univ Technol, Res Ctr Ecoenvironm Engn, Lab Adv Analyt Chem & Detect Technol, Dongguan 523808, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Guangzhou Inst Geochem, Guangdong Key Lab Environm Resources Utilizat & Pr, Guangzhou 510640, Peoples R China 5.Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Liujun,Tang, Caiming,Yu, Zhiqiang,et al. A comprehensive characterization biotransformation of chlorinated paraffin by human and carp liver microsomes via liquid chromatography-high-resolution mass spectrometry and screening algorithm[J]. ENVIRONMENT INTERNATIONAL,2025,195:11. |
| APA | Chen, Liujun,Tang, Caiming,Yu, Zhiqiang,Zeng, Yanhong,Mai, Bixian,&Luo, Xiaojun.(2025).A comprehensive characterization biotransformation of chlorinated paraffin by human and carp liver microsomes via liquid chromatography-high-resolution mass spectrometry and screening algorithm.ENVIRONMENT INTERNATIONAL,195,11. |
| MLA | Chen, Liujun,et al."A comprehensive characterization biotransformation of chlorinated paraffin by human and carp liver microsomes via liquid chromatography-high-resolution mass spectrometry and screening algorithm".ENVIRONMENT INTERNATIONAL 195(2025):11. |
入库方式： OAI收割
来源：广州地球化学研究所
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