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Thermo-Optoplasmonic Single-Molecule Sensing on Optical Microcavities

文献类型：期刊论文

作者Toropov, Nikita A.3,4,5; Houghton, Matthew C.2,5; Yu, Deshui1; Vollmer, Frank5
刊名ACS NANO
出版日期2024-06-26
页码13
关键词microresonator plasmon protein tryptophan sensor absorption
ISSN号1936-0851
DOI10.1021/acsnano.4c00877
英文摘要Whispering-gallery-mode (WGM) resonators are powerful instruments for single-molecule sensing in biological and biochemical investigations. WGM sensors leveraged by plasmonic nanostructures, known as optoplasmonic sensors, provide sensitivity down to single atomic ions. In this article, we describe that the response of optoplasmonic sensors upon the attachment of single protein molecules strongly depends on the intensity of WGM. At low intensity, protein binding causes red shifts of WGM resonance wavelengths, known as the reactive sensing mechanism. By contrast, blue shifts are obtained at high intensities, which we explain as thermo-optoplasmonic (TOP) sensing, where molecules transform absorbed WGM radiation into heat. To support our conclusions, we experimentally investigated seven molecules and complexes; we observed blue shifts for dye molecules, amino acids, and anomalous absorption of enzymes in the near-infrared spectral region. As an example of an application, we propose a physical model of TOP sensing that can be used for the development of single-molecule absorption spectrometers.
WOS关键词WHISPERING-GALLERY MODES ; LABEL-FREE ; PROTEIN ; ABSORPTION ; SHIFT
资助项目UKRI Engineering and Physical Sciences Research Council[EP/T002875/1] ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership[BB/T008741/1]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:001255677400001
出版者AMER CHEMICAL SOC
资助机构UKRI Engineering and Physical Sciences Research Council ; UKRI Engineering and Physical Sciences Research Council ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership ; UKRI Engineering and Physical Sciences Research Council ; UKRI Engineering and Physical Sciences Research Council ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership ; UKRI Engineering and Physical Sciences Research Council ; UKRI Engineering and Physical Sciences Research Council ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership ; UKRI Engineering and Physical Sciences Research Council ; UKRI Engineering and Physical Sciences Research Council ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership ; UKRI Biotechnology and Biological Sciences Research Council-funded South West Biosciences Doctoral Training Partnership
源URL[http://210.72.145.45/handle/361003/14498]  
专题国家授时中心_量子频标研究室
通讯作者Vollmer, Frank
作者单位1.Chinese Acad Sci, Natl Time Serv Ctr, Xian 710600, Peoples R China
2.Univ Bath, Dept Life Sci, Bath BA2 7AX, England
3.Harbin Engn Univ, Qingdao Innovat & Dev Ctr, Qingdao 266000, Shandong, Peoples R China
4.Univ Southampton, Optoelect Res Ctr, Southampton SO17 1BJ, England
5.Univ Exeter, Dept Phys & Astron, Exeter EX4 4QD, England
推荐引用方式
GB/T 7714		 Toropov, Nikita A.,Houghton, Matthew C.,Yu, Deshui,et al. Thermo-Optoplasmonic Single-Molecule Sensing on Optical Microcavities[J]. ACS NANO,2024:13.
APA Toropov, Nikita A.,Houghton, Matthew C.,Yu, Deshui,&Vollmer, Frank.(2024).Thermo-Optoplasmonic Single-Molecule Sensing on Optical Microcavities.ACS NANO,13.
MLA Toropov, Nikita A.,et al."Thermo-Optoplasmonic Single-Molecule Sensing on Optical Microcavities".ACS NANO (2024):13.

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