HPRNA: Predicting synergistic drug combinations for angina pectoris based on human pathway relationship network algorithm
文献类型：期刊论文
| 作者 | Zhou, Mengyao3,6; Xu MF(徐梦凡)2,6; Zhang, Xiangling1; Xing, Xiaochun1; Li, Yang5; Wang, Guanghui4; Yan, Guiying3,6 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2025-02-06 |
| 卷号 | 20期号:2页码:15 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0318368 |
| 通讯作者 | Yan, Guiying(yangy@amt.ac.cn) |
| 英文摘要 | Over the years, synergistic drug combinations therapies have attracted widespread attention due to its advantages of overcoming drug resistance, increasing treatment efficacy and decreasing toxicity. Compared to lengthy medical drugs experimental screening, mathematical models and algorithms show great potential in synergistic drug combinations prediction. In this paper, we introduce a novel mathematical algorithm, the Human Pathway Relationship Network Algorithm (HPRNA), which is designed to predict synergistic drug combinations for angina pectoris. We first reconstruct a novel angina pectoris drug dataset, which include drug name, drug metabolism, chemical formula, targets and pathways, then construct a comprehensive human pathway network based on the genetic similarity of the pathways which contain information about the targets. Finally, we introduce a novel indicator to calculate drug pair scores which measure the likelihood of forming synergistic drug combination. Experimental results on angina pectoris drug datasets convincingly demonstrate that the HPRNA makes efficient use of target and pathway information and is superior to previous algorithms. |
| 分类号 | 二类/Q1 |
| 资助项目 | National Natural Science Foundation of China[12231018] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:001435274300098 |
| 资助机构 | National Natural Science Foundation of China |
| 其他责任者 | Yan, Guiying |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/100691]  |
| 专题 | 力学研究所_流固耦合系统力学重点实验室(2012-) |
| 作者单位 | 1.Tianjin Forth Cent Hosp, Tianjin, Peoples R China; 2.Chinese Acad Sci, Inst Mech, Key Lab Mech Fluid solid Coupling Syst, Beijing, Peoples R China; 3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China; 4.Shandong Univ, Jinan, Peoples R China 5.Tianjin Med Univ Canc Inst & Hosp, Tianjin Med Univ, Tianjin, Peoples R China; 6.Univ Chinese Acad Sci, Beijing, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhou, Mengyao,Xu MF,Zhang, Xiangling,et al. HPRNA: Predicting synergistic drug combinations for angina pectoris based on human pathway relationship network algorithm[J]. PLOS ONE,2025,20(2):15. |
| APA | Zhou, Mengyao.,徐梦凡.,Zhang, Xiangling.,Xing, Xiaochun.,Li, Yang.,...&Yan, Guiying.(2025).HPRNA: Predicting synergistic drug combinations for angina pectoris based on human pathway relationship network algorithm.PLOS ONE,20(2),15. |
| MLA | Zhou, Mengyao,et al."HPRNA: Predicting synergistic drug combinations for angina pectoris based on human pathway relationship network algorithm".PLOS ONE 20.2(2025):15. |
入库方式： OAI收割
来源：力学研究所
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