Effect of Transcatheter Edge-to-Edge Repair on Left Ventricular Flow Features
文献类型：期刊论文
| 作者 | He XY(何心怡); Feng, Shuyi; Wu F(吴凡); Wang HP(王洪平); Wang SZ(王士召); Pan, Xiangbin |
| 刊名 | CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
 |
| 出版日期 | 2025-04-03 |
| 页码 | 14 |
| 关键词 | Mitral regurgitation Left ventricular flow features MitraClip Hemodynamics TEER |
| ISSN号 | 1869-408X |
| DOI | 10.1007/s13239-025-00781-2 |
| 通讯作者 | Wang, Hongping(hpwang@imech.ac.cn) ; Pan, Xiangbin(panxiangbin@fuwaihospital.org) |
| 英文摘要 | Purpose This study aims to investigate the effects of transcatheter edge-to-edge repair (TEER) on left ventricular hemodynamics and its potential implications for patient health. Methods An in vitro experimental platform was designed to replicate the anatomical and functional characteristics of the left ventricle (LV). This platform integrates native porcine mitral and aortic valves with a patient-specific 3D-printed silicone LV. The LV hemodynamics after TEER is assessed using echocardiography and particle image velocimetry, focusing on critical indices such as vorticity, Reynolds shear stress (RSS), viscous shear stress (VSS), and energy dissipation rate (epsilon). Results TEER effectively reduces the degree of mitral regurgitation (MR); however, it significantly increases RSS, VSS, and epsilon due to the formation of numerous small-scale vortices in the LV. Conclusion These hemodynamic changes may lead to adverse left ventricular remodeling, red blood cell damage, and reduced cardiac pumping efficiency, which have to be taken into consideration to optimize the TEER procedure and improve patient outcomes. |
| 分类号 | Q4 |
| WOS关键词 | REGURGITATION ; MANAGEMENT ; PATTERNS |
| 资助项目 | National Natural Science Foundation of China (NSFC) Basic Science Center Program for 'Multiscale Problems in Nonlinear Mechanics'[11988102] ; NSFC[12072348] |
| WOS研究方向 | Cardiovascular System & Cardiology ; Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:001459055500001 |
| 资助机构 | National Natural Science Foundation of China (NSFC) Basic Science Center Program for 'Multiscale Problems in Nonlinear Mechanics' ; NSFC |
| 其他责任者 | 王洪平 ; Pan, Xiangbin |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/100780]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | He XY,Feng, Shuyi,Wu F,et al. Effect of Transcatheter Edge-to-Edge Repair on Left Ventricular Flow Features[J]. CARDIOVASCULAR ENGINEERING AND TECHNOLOGY,2025:14. |
| APA | 何心怡,Feng, Shuyi,吴凡,王洪平,王士召,&Pan, Xiangbin.(2025).Effect of Transcatheter Edge-to-Edge Repair on Left Ventricular Flow Features.CARDIOVASCULAR ENGINEERING AND TECHNOLOGY,14. |
| MLA | 何心怡,et al."Effect of Transcatheter Edge-to-Edge Repair on Left Ventricular Flow Features".CARDIOVASCULAR ENGINEERING AND TECHNOLOGY (2025):14. |
入库方式： OAI收割
来源：力学研究所
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