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Ultrasensitive magnetic nanomechanical biosensors for simultaneous detection of multiple cardiovascular disease biomarkers in a single blood drop

文献类型：期刊论文

作者Chen, Qiubo3; Zhang, Lin1; Qiao, Zihan3; Yang, Yipeng3; Wu, Wenjie3; Wang, Chen3; Chen, Jian1; Wu SQ2,3; Zhang, Qingchuan3
刊名BIOSENSORS & BIOELECTRONICS
出版日期2025-07-15
卷号280页码:10
关键词Cardiovascular diseases (CVD) Early diagnosis Ultrasensitive sensor Magnetic force Microcantilever array A drop of blood Nanomechanics
ISSN号0956-5663
DOI10.1016/j.bios.2025.117448
通讯作者Wu, Shangquan(wushq@ustc.edu.cn) ; Zhang, Qingchuan(zhangqc@ustc.edu.cn)
英文摘要Cardiovascular disease (CVD) is the number one cause of death, and the early prevention of CVD is considered the most useful and cost-effective intervention strategy, highlighting the critical need for frequent and long-term monitoring cardiac abnormalities. However, traditional blood test methods often require considerable volumes of blood (>10 mL), which could burden physical health, especially for individuals in poor health. Here, we report a novel magnetic nanomechanical sensor (MNS) capable of simultaneously detecting multiple CVD biomarkers (brain natriuretic peptide (BNP), cardiac troponin I (cTnI) and creatine kinase MB (CK-MB)) in a single drop of blood (<1 mu L). Relying on the force-sensitive microcantilevers and robust magnetic force, MNS can directly detect blood samples with a detection sensitivity for BNP as low as 0.1 pg/mL. Moreover, we improved the MNS sensitivity by reducing nonspecific adsorption and focusing the force on specific locations on the sensor surface. The effectiveness of the MNS was demonstrated through the detection of samples from clinical CVD patients and healthy individuals. Given its ultrasensitive, trace-sample requirement, and ability to monitor multiple biomarkers, the MNS holds significant potential for frequent and long-term monitoring-not only for CVD but also for the prevention and management of other chronic diseases.
分类号一类
WOS关键词TROPONIN-I ; PREDICTOR ; BINDING ; ASSAY
资助项目National Natural Science Foundation of China[12232017] ; National Natural Science Foundation of China[12222212] ; National Natural Science Foundation of China[12072339] ; National Science and Technology Major Project[J2019-V-0006-0100]
WOS研究方向Biophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics
语种英语
WOS记录号WOS:001466479500001
资助机构National Natural Science Foundation of China ; National Science and Technology Major Project
其他责任者Wu SQ，Zhang, Qingchuan
源URL[http://dspace.imech.ac.cn/handle/311007/101067]  
专题力学研究所_非线性力学国家重点实验室
作者单位1.Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Crit Care Med, Div Life Sci & Med, Hefei 230001, Peoples R China;
2.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, 15 Beisihuan West Rd, Beijing 100190, Peoples R China
3.Univ Sci & Technol China, Dept Modern Mech, CAS Key Lab Mech Behav & Design Mat, Hefei 230027, Anhui, Peoples R China;
推荐引用方式
GB/T 7714		 Chen, Qiubo,Zhang, Lin,Qiao, Zihan,et al. Ultrasensitive magnetic nanomechanical biosensors for simultaneous detection of multiple cardiovascular disease biomarkers in a single blood drop[J]. BIOSENSORS & BIOELECTRONICS,2025,280:10.
APA Chen, Qiubo.,Zhang, Lin.,Qiao, Zihan.,Yang, Yipeng.,Wu, Wenjie.,...&Zhang, Qingchuan.(2025).Ultrasensitive magnetic nanomechanical biosensors for simultaneous detection of multiple cardiovascular disease biomarkers in a single blood drop.BIOSENSORS & BIOELECTRONICS,280,10.
MLA Chen, Qiubo,et al."Ultrasensitive magnetic nanomechanical biosensors for simultaneous detection of multiple cardiovascular disease biomarkers in a single blood drop".BIOSENSORS & BIOELECTRONICS 280(2025):10.

入库方式： OAI收割

来源：力学研究所

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