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Ultra-sensitive magnetic nanomechanical array sensor based on graphene oxide for single bacterial cell detection

文献类型：期刊论文

作者Qiao, Zihan2,4; Mei, Kainan2; Wang, Yu2; Yan, Tianhao5; Zhang, Shubo1,6; Chen, Qiubo2; Chen, Ye2; Wang, Chen2; Ren, Tianxiang2; Wu SQ2,3
刊名NANO RESEARCH
出版日期2025-04-01
卷号18期号:4页码:14
关键词bacterial detection microcantilever array graphene oxide magnetic force nanomechanical sensor
ISSN号1998-0124
DOI10.26599/NR.2025.94907290
通讯作者Wu, Shangquan(wushq@ustc.edu.cn) ; Zhang, Qingchuan(zhangqc@ustc.edu.cn)
英文摘要Pathogenic bacterial infections pose major health threats and economic burdens. Rapid and highly sensitive biochemical sensors are essential for bacterial detection in food safety and clinical applications. Here, we introduce a graphene oxide (GO)-based magnetic nanomechanical array sensor that utilizes the large surface area of GO to bind more magnetic nanoparticles (MNPs) and aptamers. Rapid and ultra-sensitive detection can be achieved even at extremely low target concentrations. This approach can directly detect a single Escherichia coli cell without time-consuming bacterial culture, and sensor showed good specificity, reproducibility, stability, and stance to interference, and could detect 1 CFUmL(-1) Escherichia coli in milk. Moreover, we realized the simultaneous detection of two bacteria at extremely low concentrations, which proved that the sensor had the potential for high-throughput detection. In addition, for extremely low-concentration samples (< 100 CFUmL(-1)), we controlled the magnetic force at the tip of the microcantilever, greatly enhancing its deflection and sensitivity. This method provides a novel and ultrasensitive method for the timely detection of pathogenic bacteria, and can also be applied to the highly sensitive detection of other targets such as DNA, small molecules, proteins, and viruses by using different probes. Our research provides a promising tool for effective, rapid and highly sensitive detection in the field of public health and food safety.
分类号一类
WOS关键词PATHOGENIC BACTERIA ; RAPID DETECTION ; MICROCANTILEVER ; BIOSENSOR
资助项目National Natural Science Foundation of China[12232017] ; National Natural Science Foundation of China[12222212] ; National Natural Science Foundation of China[12072339]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:001469484500001
资助机构National Natural Science Foundation of China
其他责任者Wu, Shangquan，Zhang, Qingchuan
源URL[http://dspace.imech.ac.cn/handle/311007/101088]  
专题力学研究所_非线性力学国家重点实验室
作者单位1.Nanyang Technol Univ, Coll Engn, Sch Mech & Aerosp Engn, Singapore 639798, Singapore;
2.Univ Sci & Technol China, Dept Modern Mech, CAS Key Lab Mech Behav & Design Mat, Hefei 230027, Peoples R China;
3.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China;
4.Univ Sci & Technol China, Hefei Natl Res Ctr Phys Sci Microscale, Dept Chem Phys, Hefei 230026, Peoples R China
5.Jilin Univ, Coll Basic Med Sci, Dept Cell Biol & Med Genet, Changchun 130021, Peoples R China;
6.Inst Flexible Elect Technol THU, Jiaxing 314000, Peoples R China;
推荐引用方式
GB/T 7714		 Qiao, Zihan,Mei, Kainan,Wang, Yu,et al. Ultra-sensitive magnetic nanomechanical array sensor based on graphene oxide for single bacterial cell detection[J]. NANO RESEARCH,2025,18(4):14.
APA Qiao, Zihan.,Mei, Kainan.,Wang, Yu.,Yan, Tianhao.,Zhang, Shubo.,...&Zhang, Qingchuan.(2025).Ultra-sensitive magnetic nanomechanical array sensor based on graphene oxide for single bacterial cell detection.NANO RESEARCH,18(4),14.
MLA Qiao, Zihan,et al."Ultra-sensitive magnetic nanomechanical array sensor based on graphene oxide for single bacterial cell detection".NANO RESEARCH 18.4(2025):14.

入库方式： OAI收割

来源：力学研究所

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