New Polyhydroxysteroids Derivatives from Starfish Asterias amurensis Induce Embryotoxicity in Marine Medaka
文献类型：期刊论文
| 作者 | Li, Xiaodong1; Lu, Zhen1; Wang, Derui1,2; Yan, Zhi1; Yin, Xiuli1; Xu, Youhou2; Wang, Song3; Li, Ke1,4 |
| 刊名 | JOURNAL OF CHEMICAL ECOLOGY
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| 出版日期 | 2025-04-01 |
| 卷号 | 51期号:2页码:14 |
| 关键词 | Asterias amurensis Polyhydroxysteroid Embryotoxicity Chemical defense Oryzias melastigma |
| ISSN号 | 0098-0331 |
| DOI | 10.1007/s10886-025-01594-2 |
| 通讯作者 | Li, Ke(kli@yic.ac.cn) |
| 英文摘要 | In recent years, multiple population outbreaks of the Northern Pacific starfish (Asterias amurensis) have been documented off the coast of Qingdao. Starfish use chemosensation to regulate their life history and interactions with the environment, with their secondary metabolites serving as deterrents and dispersal agents against predators. While the eggs of marine fish are passive and susceptible, we hypothesized that the secondary metabolites of A. amurensis may cause embryotoxicity and exhibit a more insidious chemical function. In this study, we identified the secondary metabolites of A. amurensis collected from the Yellow Sea of China. Five new polyhydroxysteroid derivatives, (22Z)-26-O-beta-D-xylopyranosyl-24-nor-5 alpha-cholestane-22(23)-ene-3 beta,6 alpha,7 alpha,15 alpha,26-pentaol (1), (24S)-O-beta-D-xylopyranosyl-5 alpha-cholestane-3 beta,6 alpha,7 alpha,15 alpha,24-pentaol (2), (22E,24S)-24-O-[4-O-sulfo-beta-D-xylopyranosyl]-5 alpha-cholest-9(11)-ene-3 beta,6 alpha,7 alpha,15 beta,24-pentol (3), (24S)-methylene-28-O-sulfo-5 alpha-cholestane-3 beta,6 alpha,15 alpha,24-tetraol (4), and 6 alpha-O-sulfo-5 alpha-cholestane-3 beta,5-diol (5), together with two known steroids, (24S)-24-methyl-5 alpha-cholestane-3 beta,6 alpha,15 beta,24,24'-pentaol (6) and (20E)-3 beta,6 alpha-dihydroxy-5 alpha-cholesta-9(11),20(22)-dien-23-one (7) were identified from the n-butanol extract. NMR and HRESI-MS were employed for structure elucidations. The embryotoxicity and teratogenicity of the isolated compounds were assessed using embryos of marine medaka (Oryzias melastigma). Compound 5 induced significantly higher mortality rates than other compounds, causing up to 70% mortality at 96 hpf, with a 96 h-LC50 of 60.51 mu M. |
| WOS关键词 | GROWTH-INHIBITORY ACTIVITY ; STEROIDS ; SAPONINS ; EMBRYOS ; SPONGE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001443817900001 |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.yic.ac.cn/handle/133337/40142]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Li, Ke |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Beibu Gulf Univ, Coll Marine Sci, Qinzhou 535011, Peoples R China 3.Jiangsu Ocean Univ, Coinnovat Ctr Jiangsu Marine Bioind Technol, Lianyungang 222005, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xiaodong,Lu, Zhen,Wang, Derui,et al. New Polyhydroxysteroids Derivatives from Starfish Asterias amurensis Induce Embryotoxicity in Marine Medaka[J]. JOURNAL OF CHEMICAL ECOLOGY,2025,51(2):14. |
| APA | Li, Xiaodong.,Lu, Zhen.,Wang, Derui.,Yan, Zhi.,Yin, Xiuli.,...&Li, Ke.(2025).New Polyhydroxysteroids Derivatives from Starfish Asterias amurensis Induce Embryotoxicity in Marine Medaka.JOURNAL OF CHEMICAL ECOLOGY,51(2),14. |
| MLA | Li, Xiaodong,et al."New Polyhydroxysteroids Derivatives from Starfish Asterias amurensis Induce Embryotoxicity in Marine Medaka".JOURNAL OF CHEMICAL ECOLOGY 51.2(2025):14. |
入库方式： OAI收割
来源：烟台海岸带研究所
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