The roles of a MiRNA and its targeted methyltransferase 3 in carotenoid accumulation in adductor muscles of QN orange scallops
文献类型：期刊论文
| 作者 | Song, Junlin1; Sun, Xiao1; Wang, Chunde2,3 |
| 刊名 | BMC GENOMICS
 |
| 出版日期 | 2025-03-06 |
| 卷号 | 26期号:1页码:11 |
| 关键词 | QN orange scallops Carotenoid accumulation MiRNA Methyltransferase 3 N6-methyladenosine |
| ISSN号 | 1471-2164 |
| DOI | 10.1186/s12864-025-11388-1 |
| 通讯作者 | Wang, Chunde(chundewang2007@163.com) |
| 英文摘要 | BackgroundQN Orange scallops are interspecific hybrids with orange adductor muscles that are rich in carotenoids. In this study, analysis of miRNA expression profiles was performed to explore possible regulatory patterns involved in carotenoid accumulation in adductor muscles of QN Orange scallops.ResultsA total of 91 differentially expressed miRNA between the white and orange adductor muscles were identified. GO and KEGG analysis of target genes of differentially expressed miRNAs revealed enrichments in the transmembrane transporter activity-related pathways, kinase activity-related pathways, signal transduction-related pathways, ATP binding cassette transporters (ABC transporters), retinol metabolism, lipid-related metabolism, and calcium signaling pathway. In particular, miRNA Contig1462_36180, which was shown to negatively regulate the activity of methyltransferase 3 (METTL3) by dual-luciferase reporter assay, may play a pivotal role in the accumulation of carotenoids. Furthermore, METTL3 interference seemed to reduce the pectenoxanthin content and m6A level.ConclusionIt is thus speculated that Contig1462_36180 may regulate m6A methylation by regulating METTL3, which in turn affects pectenoxanthin accumulation in QN Orange scallops. |
| WOS关键词 | MESSENGER-RNA ; BOHAI RED ; METHYLATION |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:001439691400004 |
| 资助机构 | National Natural Science Foundation ; Shandong Province Natural Science Foundation ; Earmarked Fund for Agriculture Seed Improvement Project of Shandong Province ; Earmarked Fund for Shandong Modern Agro-Industry Technology Research System |
| 源URL | [http://ir.yic.ac.cn/handle/133337/40152]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Wang, Chunde |
| 作者单位 | 1.Qingdao Agr Univ, Anal & Testing Ctr, Qingdao 266109, Peoples R China 2.Qingdao Agr Univ, Sch Marine Sci & Engn, Qingdao 266109, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Junlin,Sun, Xiao,Wang, Chunde. The roles of a MiRNA and its targeted methyltransferase 3 in carotenoid accumulation in adductor muscles of QN orange scallops[J]. BMC GENOMICS,2025,26(1):11. |
| APA | Song, Junlin,Sun, Xiao,&Wang, Chunde.(2025).The roles of a MiRNA and its targeted methyltransferase 3 in carotenoid accumulation in adductor muscles of QN orange scallops.BMC GENOMICS,26(1),11. |
| MLA | Song, Junlin,et al."The roles of a MiRNA and its targeted methyltransferase 3 in carotenoid accumulation in adductor muscles of QN orange scallops".BMC GENOMICS 26.1(2025):11. |
入库方式： OAI收割
来源：烟台海岸带研究所
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