Pectiniferosides A-J: Diversified Glycosides of Polyhydroxy Steroids Isolated from the Sea Star Patiria (=Asterina) pectinifera
文献类型：期刊论文
| 作者 | Zhang, Ranran1,2; Lu, Zhen1; Wang, Derui3; Yan, Zhi1; Sun, Xueting1; Li, Xiaodong1; Yin, Xiuli1; Wang, Song4; Li, Ke1,5 |
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2024-12-01 |
| 卷号 | 22期号:12页码:19 |
| 关键词 | |
| DOI | 10.3390/md22120545 |
| 通讯作者 | Li, Ke(kli@yic.ac.cn) |
| 英文摘要 | To optimize the utilization of the sea star Patiria (=Asterina) pectinifera, which has demonstrated potential pharmaceutical properties in Chinese folk medicine, ten glycosides of polyhydroxy steroids, pectiniferosides A-J (1-10), were isolated and characterized. These compounds possess 3 beta, 6 alpha, 8, 15 alpha (or beta), 16 beta-pentahydroxycholestane aglycones with sulfated and (or) methylated monosaccharides. The chemical structures of 1-10 were determined using NMR spectroscopy and HR-ESI-MS. The discovery of saponins with multiple substitution patterns in sea stars exemplified the molecular diversity of secondary metabolites in marine echinoderms. These compounds exhibited no embryotoxicity or teratogenicity at a concentration of 100 mu M in a bioassay with marine medaka (Oryzias melastigma) embryos, implying that these compounds may not be ecologically toxic to marine fish embryos. In addition, none of the compounds exhibited significant cytotoxicity against five human cancer cell lines at 40 mu M or anti-inflammatory activities at 50 mu M, suggesting their potential for further structural optimization to enhance bioactivity. The research on the constituents of P. pectinifera provides a potential foundation for drug development and marine ecotoxicology. |
| WOS关键词 | POLAR STEROIDS ; TRITERPENOID SAPONINS ; ASTEROSAPONIN-P1 ; OLIGOGLYCOSIDES ; COMPONENTS ; ASTEROIDEA ; PLANT ; ASSAY |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001384753700001 |
| 资助机构 | National Natural Science Foundation of China ; Yantai Institute of Coastal Zone Research's seed project ; Yantai Science and Technology Innovation Development Program ; Shuangbai Plan ; Yantai Municipal City |
| 源URL | [http://ir.yic.ac.cn/handle/133337/40256]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Li, Ke |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 3.Beibu Gulf Univ, Coll Marine Sci, Qinzhou 535011, Peoples R China 4.Jiangsu Ocean Univ, Coinnovat Ctr Jiangsu Marine Bioind Technol, Lianyungang 222005, Peoples R China 5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ranran,Lu, Zhen,Wang, Derui,et al. Pectiniferosides A-J: Diversified Glycosides of Polyhydroxy Steroids Isolated from the Sea Star Patiria (=Asterina) pectinifera[J]. MARINE DRUGS,2024,22(12):19. |
| APA | Zhang, Ranran.,Lu, Zhen.,Wang, Derui.,Yan, Zhi.,Sun, Xueting.,...&Li, Ke.(2024).Pectiniferosides A-J: Diversified Glycosides of Polyhydroxy Steroids Isolated from the Sea Star Patiria (=Asterina) pectinifera.MARINE DRUGS,22(12),19. |
| MLA | Zhang, Ranran,et al."Pectiniferosides A-J: Diversified Glycosides of Polyhydroxy Steroids Isolated from the Sea Star Patiria (=Asterina) pectinifera".MARINE DRUGS 22.12(2024):19. |
入库方式： OAI收割
来源：烟台海岸带研究所
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