Potential roles of the sirtuins in promoting longevity for larger Argopecten scallops
文献类型：期刊论文
| 作者 | Zhao, Yang1,3; Ning, Junhao1; Wang, Yuan1,3; Liu, Guilong5; Xu, Xin5; Wang, Chunde1,4; Lu, Xia2 |
| 刊名 | MARINE LIFE SCIENCE & TECHNOLOGY
 |
| 出版日期 | 2025-03-04 |
| 页码 | 18 |
| 关键词 | Scallops
|
| ISSN号 | 2096-6490 |
| DOI | 10.1007/s42995-024-00269-3 |
| 通讯作者 | Wang, Chunde(chundewang2007@163.com) ; Lu, Xia(luxia_0202@163.com) |
| 英文摘要 | Annual bay scallops are commercially significant bivalve species for fisheries and aquaculture, but their small size and severe inbreeding depression impede the development of their industry. Some interspecific hybrids of bay scallops and peruvian scallops show longer lifespans and significantly greater sizes, which may result from the longevity genes in the latter (7-10 years). Sirtuins (SIRTs) play pivotal roles in the genetic control of aging in various model species and human beings. However, the role of SIRTs in longevity has not been systematically studied in aquatic animals. In this study, different gene numbers, sequences, structures and tandem duplications of SIRTs were first identified between the two scallops through genome-wide analysis. Cloning and characteristics of the SIRT1 and SIRT6 ORFs revealed dramatic variations in amino acids between the two scallops, which may cause intrinsic differences in function for longevity regulation. In particular, the amino acid variations in the N-terminus may auto-regulate conformations, causing intrinsic differences in catalytic activity for longevity regulation. The robust expression of SIRT1 and SIRT6-2 in peruvian scallops suggested they may exert a role in extending the lifespan. Nutrient restriction (NR) could promote lifespan in terrestrial model organisms, and the SIRTs and their related genes responded to NR for longevity in scallops; peruvian scallops showed a higher ability of autophagy. This study provides potential biomarkers for breeding long-lived larger scallop hybrids for the sustainability of aquaculture. Moreover, the genetic variation during evolution in the two scallops provides a foundation for further research on the longevity function of the SIRTs. |
| WOS关键词 | IRRADIANS-IRRADIANS LAMARCK ; BAY SCALLOP ; CALORIE RESTRICTION ; LIFE-SPAN ; INBREEDING DEPRESSION ; SIRT1 ; HOMOLOG ; STRESS ; IDENTIFICATION ; EXPRESSION |
| WOS研究方向 | Marine & Freshwater Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001436467700001 |
| 资助机构 | National Natural Science Foundation of China ; Scientific and Technological Project of Yantai, Shandong Province ; Earmarked Fund for Shandong Modern Argro-Industry Technology Research System ; Earmarked Fund for Agriculture Seed Improvement Project of Shandong Province |
| 源URL | [http://ir.yic.ac.cn/handle/133337/40340]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Wang, Chunde; Lu, Xia |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresour, Yantai 264003, Peoples R China 2.Yantai Univ, Sch Ocean, Yantai 264005, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Qingdao Agr Univ, Coll Marine Sci & Engn, Qingdao 266109, Peoples R China 5.Yantai Spring Sea AquaSeed Ltd, Yantai 264006, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Yang,Ning, Junhao,Wang, Yuan,et al. Potential roles of the sirtuins in promoting longevity for larger Argopecten scallops[J]. MARINE LIFE SCIENCE & TECHNOLOGY,2025:18. |
| APA | Zhao, Yang.,Ning, Junhao.,Wang, Yuan.,Liu, Guilong.,Xu, Xin.,...&Lu, Xia.(2025).Potential roles of the sirtuins in promoting longevity for larger Argopecten scallops.MARINE LIFE SCIENCE & TECHNOLOGY,18. |
| MLA | Zhao, Yang,et al."Potential roles of the sirtuins in promoting longevity for larger Argopecten scallops".MARINE LIFE SCIENCE & TECHNOLOGY (2025):18. |
入库方式： OAI收割
来源：烟台海岸带研究所
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