Development and research progress of microalgae as a production platform for antimicrobial peptides
文献类型：期刊论文
| 作者 | Wang, Qiaolei1; Ma, Yuyang1; Sun, Fengjie2; Wang, Kang3; Ma, Jinju1; Zhu, Bingkui1; Cao, Kai1; Shao, Yaping1; Cui, Yulin1; Zhang, Hao1 |
| 刊名 | JOURNAL OF APPLIED PHYCOLOGY
 |
| 出版日期 | 2025-03-11 |
| 页码 | 19 |
| 关键词 | Antimicrobial peptide Microalgae Expression form Expression system Aquaculture Application potential |
| ISSN号 | 0921-8971 |
| DOI | 10.1007/s10811-025-03472-6 |
| 通讯作者 | Meng, Chunxiao(mengchunxiao@126.com) ; Gao, Zhengquan(gaozhengquan@bzmc.edu.cn) |
| 英文摘要 | At present the development and application of antibiotics has shown a downward trend. This is attributed to the overuse of antibiotics leading to an increase in multidrug-resistant bacterial strains. Therefore, it is important to identify alternative antibacterial substances that can help avoid the development of resistance. Antimicrobial peptides (AMPs) are widely found in nature and are not susceptible to drug resistance, making them candidates as an alternative to traditional antibiotics. Microalgae are an important source of AMPs. Spirulina contains natural AMPs that play an important role in aquatic ecosystems. However, due to the rapid development of genetic engineering technology, other microalgae have shown significant potential for the heterologous expression of AMPs and have become a research hotspot. Among the three commonly used heterogeneous production systems (bacteria, fungi, and microalgae), microalgae have shown the main advantages of both prokaryotic and eukaryotic production systems and are expected to become a substitute production platform of AMPs. It is reported that appropriate genetic elements can be selected to express a variety of AMPs with their antibacterial activities verified in the nuclei or chloroplasts of several microalgal taxa. Due to its effective prevention of gene silencing, chloroplast expression is more advantageous than nuclear expression. In this review, we provide a brief overview of the classification of AMPs based on their secondary structure, their mechanism of action, and the natural AMPs found in microalgae. We have focused on the research progress in utilizing microalgae as a production platform for AMPs and on the application of AMPs produced by microalgae. |
| WOS关键词 | CATIONIC ANTIBACTERIAL PEPTIDE ; HUMAN GROWTH-HORMONE ; CHLAMYDOMONAS-REINHARDTII ; ESCHERICHIA-COLI ; RECOMBINANT PROTEINS ; PICHIA-PASTORIS ; GREEN-ALGA ; HAEMATOCOCCUS-PLUVIALIS ; NUCLEAR TRANSFORMATION ; CYCLIC PEPTIDE |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Marine & Freshwater Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:001441624800001 |
| 资助机构 | National Natural Science Foundation of China ; Natural Science Foundation of Shandong Province ; Scientific Research Fund of Binzhou Medical University ; Yantai Economic-Technological Development Area Innovation Pilot Project |
| 源URL | [http://ir.yic.ac.cn/handle/133337/40346]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 通讯作者 | Meng, Chunxiao; Gao, Zhengquan |
| 作者单位 | 1.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 2.Georgia Gwinnett Coll, Sch Sci & Technol, Dept Biol Sci, 1000 Univ Ctr Lane, Lawrenceville, GA 30043 USA 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Biol Resource Utilizat, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Qiaolei,Ma, Yuyang,Sun, Fengjie,et al. Development and research progress of microalgae as a production platform for antimicrobial peptides[J]. JOURNAL OF APPLIED PHYCOLOGY,2025:19. |
| APA | Wang, Qiaolei.,Ma, Yuyang.,Sun, Fengjie.,Wang, Kang.,Ma, Jinju.,...&Gao, Zhengquan.(2025).Development and research progress of microalgae as a production platform for antimicrobial peptides.JOURNAL OF APPLIED PHYCOLOGY,19. |
| MLA | Wang, Qiaolei,et al."Development and research progress of microalgae as a production platform for antimicrobial peptides".JOURNAL OF APPLIED PHYCOLOGY (2025):19. |
入库方式： OAI收割
来源：烟台海岸带研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。