C-phycocyanin and quaternized chitosan based antibiotic-free hydrogels with antioxidant and antibacterial activity for wound healing
文献类型：期刊论文
| 作者 | Zhang, Susu1; Huang, Congcong2; Sun, Zengyu1; Jiao, Penghua1; Ding, Baoqi1; Ding, Luyao1; Qi, Qianfen1; Gou, Yanzhe1; Zhang, Renlong1; He, Yanhao1 |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2025-04-01 |
| 卷号 | 302页码:16 |
| 关键词 | Hydrogel Wound dressing C-phycocyanin Quaternized chitosan PDRN |
| ISSN号 | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2025.140647 |
| 通讯作者 | He, Yanhao(ythyh@ytu.edu.cn) ; Li, Wenjun(wjli@yic.ac.cn) ; Ren, Chunguang(cgren@ytu.edu.cn) ; Wang, Linlin(wanglinlin@sdbi.edu.cn) |
| 英文摘要 | Hydrogels with antioxidant and antibacterial activities have received increasing attention in wound healing due to excessive reactive oxygen species (ROS) and bacterial infection are common issues associated with wounds. Herein, we constructed a series of hydrogels with C-phycocyanin (C-PC), quaternized chitosan (QCS) and silk fibroin protein (SF) as matrixes, which with tetrakis hydroxymethyl phosphonium sulfate (THPS) as crosslinking agent to form dynamic covalent bonds with C-PC and SF. The hydrogel exhibited excellent stretchability and compressibility, which with adhesion strength reached 15 +/- 3 kPa and rapid self-healing properties. The hydrogel possessed strong antioxidant activity with assessments of DPPH radical-scavenging capacity and total reducing power. In addition, the hydrogel possessed obvious coagulation function and good blood compatibility, which also showed strong antibacterial activity against E. coli and S. aureus. To improve the therapeutic effect, polydeoxyribonucleotide (PDRN) with the ability of promote wound healing was introduced into the hydrogel. The results showed that the hydrogel loading with PDRN possessed high biocompatibility and can promote cell migration. More importantly, the hydrogel loaded with PDRN can effectively promote wound healing by exerting anti-inflammatory and antioxidant effects, which may offer promising potential application value in the field of wound dressing and tissue repair. |
| WOS关键词 | PURIFICATION |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:001423529100001 |
| 资助机构 | Yantai University Start-up Foundation ; Shandong Business Institute Landmark Achievement Cultivation Project |
| 源URL | [http://ir.yic.ac.cn/handle/133337/40364]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 通讯作者 | He, Yanhao; Li, Wenjun; Ren, Chunguang; Wang, Linlin |
| 作者单位 | 1.Yantai Univ, Sch Pharm, Yantai 264005, Shandong, Peoples R China 2.Shandong Business Inst, Dept Food Engn, Yantai 264670, Shandong, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Susu,Huang, Congcong,Sun, Zengyu,et al. C-phycocyanin and quaternized chitosan based antibiotic-free hydrogels with antioxidant and antibacterial activity for wound healing[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2025,302:16. |
| APA | Zhang, Susu.,Huang, Congcong.,Sun, Zengyu.,Jiao, Penghua.,Ding, Baoqi.,...&Wang, Linlin.(2025).C-phycocyanin and quaternized chitosan based antibiotic-free hydrogels with antioxidant and antibacterial activity for wound healing.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,302,16. |
| MLA | Zhang, Susu,et al."C-phycocyanin and quaternized chitosan based antibiotic-free hydrogels with antioxidant and antibacterial activity for wound healing".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 302(2025):16. |
入库方式： OAI收割
来源：烟台海岸带研究所
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