Organobromine compounds in aquatic environments: Embryotoxicity linked to lipophilicity and molecular structure
文献类型：期刊论文
| 作者 | Hou, Zhihao1,2; Shi, Zhenzhen1; Lu, Zhen1; Wang, Derui3; Yan, Zhi1,2; Jiang, Yanqiu4; Li, Ke1,5 |
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2025-06-05 |
| 卷号 | 489页码:14 |
| 关键词 | Bromophenols Acute toxicity Lipophilicity Retinol metabolism Myocardial contraction |
| ISSN号 | 0304-3894 |
| DOI | 10.1016/j.jhazmat.2025.137550 |
| 通讯作者 | Li, Ke(kli@yic.ac.cn) |
| 英文摘要 | Organobromine compounds, prevalent in marine environments due to both anthropogenic activities and natural processes, have been shown to exhibit significant toxicity toward aquatic organisms. This study investigates the embryotoxicity and teratogenic effects of six bromophenol compounds using zebrafish (Danio rerio) embryos as a model. The compounds exhibited varying degrees of toxicity, with BP-6 and BP-5 showing the lowest LC50 values. The study identified distinct embryonic malformations, including venous sinus edema, pericardial cysts, and craniofacial malformations. A correlation was observed between the toxicity of the bromophenols and their lipophilicity, with higher lipophilicity compounds demonstrating greater toxicity. Mechanistic insights into the toxicity of bromophenols were further explored through transcriptomic analysis, which identified significant effects on retinol metabolism, modulation of myocardial contraction via Ca2+/Na+ ion flux, stimulation of nonspecific immune responses, and suppression of primary bile acid synthesis. BP-2 exposure significantly altered calcium signaling and bile acid biosynthesis, indicating a potential mechanism for its enhanced toxicity. These findings underscore the need for further investigation into the environmental and health impacts of bromophenols, particularly as they accumulate in marine ecosystems and the food chain. |
| WOS关键词 | POLYBROMINATED DIPHENYL ETHERS ; DISINFECTION BY-PRODUCTS ; DEVELOPMENTAL TOXICITY ; FLAME RETARDANTS ; RISK-ASSESSMENT ; VITAMIN-A ; ZEBRAFISH ; BROMOPHENOLS ; WATER ; OXIDATION |
| WOS研究方向 | Engineering ; Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:001426470700001 |
| 资助机构 | National Key R & D Program of China ; National Natural Science Foundation of China ; Seed Project of the Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences |
| 源URL | [http://ir.yic.ac.cn/handle/133337/40373]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物资源高效利用研究与发展中心 |
| 通讯作者 | Li, Ke |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Beibu Gulf Univ, Coll Marine Sci, Qinzhou 535011, Peoples R China 4.Shanghai Ocean Univ, Key Lab Freshwater Aquat Genet Resources Certifica, Minist Agr & Rural Affairs, Shanghai 210306, Peoples R China 5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hou, Zhihao,Shi, Zhenzhen,Lu, Zhen,et al. Organobromine compounds in aquatic environments: Embryotoxicity linked to lipophilicity and molecular structure[J]. JOURNAL OF HAZARDOUS MATERIALS,2025,489:14. |
| APA | Hou, Zhihao.,Shi, Zhenzhen.,Lu, Zhen.,Wang, Derui.,Yan, Zhi.,...&Li, Ke.(2025).Organobromine compounds in aquatic environments: Embryotoxicity linked to lipophilicity and molecular structure.JOURNAL OF HAZARDOUS MATERIALS,489,14. |
| MLA | Hou, Zhihao,et al."Organobromine compounds in aquatic environments: Embryotoxicity linked to lipophilicity and molecular structure".JOURNAL OF HAZARDOUS MATERIALS 489(2025):14. |
入库方式： OAI收割
来源：烟台海岸带研究所
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