Advancements of astaxanthin production in Haematococcus pluvialis: Update insight and way forward
文献类型：期刊论文
| 作者 | Cui, Hongli1; Zhu, Xiaoli2; Yu, Xiao3; Li, Siming3; Wang, Kang1; Wei, Le1; Li, Runzhi3; Qin, Song1 |
| 刊名 | BIOTECHNOLOGY ADVANCES
 |
| 出版日期 | 2025-03-01 |
| 卷号 | 79页码:33 |
| 关键词 | Astaxanthin production Haematococcus pluvialis Biosynthetic pathway Enhancement strategies Regulation mechanisms Integrated and systematic solutions |
| ISSN号 | 0734-9750 |
| DOI | 10.1016/j.biotechadv.2025.108519 |
| 通讯作者 | Qin, Song(sqin@yic.ac.cn) |
| 英文摘要 | The global market demand for natural astaxanthin (AXT) is growing rapidly owing to its potential human health benefits and diverse industry applications, driven by its safety, unique structure, and special function. Currently, the alga Haematococcus pluvialis (alternative name H. lacustris) has been considered as one of the best large-scale producers of natural AXT. However, the industry's further development faces two main challenges: the limited cultivation areas due to light-dependent AXT accumulation and the low AXT yield coupled with high production costs resulting from complex, time-consuming upstream biomass culture and downstream AXT extraction processes. Therefore, it is urgently to develop novel strategies to improve the AXT production in H. pluvialis to meet industrial demands, which makes its commercialization cost-effective. Although several strategies related to screening excellent target strains, optimizing culture condition for high biomass yield, elucidating the AXT biosynthetic pathway, and exploiting effective inducers for high AXT content have been applied to enhance the AXT production in H. pluvialis, there are still some unsolved and easily ignored perspectives. In this review, firstly, we summarize the structure and function of natural AXT focus on those from the algal H. pluvialis. Secondly, the latest findings regarding the AXT biosynthetic pathway including spatiotemporal specificity, transport, esterification, and storage are updated. Thirdly, we systematically assess enhancement strategies on AXT yield. Fourthly, the regulation mechanisms of AXT accumulation under various stresses are discussed. Finally, the integrated and systematic solutions for improving AXT production are proposed. This review not only fills the existing gap about the AXT accumulation, but also points the way forward for AXT production in H. pluvialis. |
| WOS关键词 | GREEN-ALGA HAEMATOCOCCUS ; BETA-CAROTENE KETOLASE ; MICROALGA CHLORELLA-ZOFINGIENSIS ; INTEGRATED CARBON CAPTURE ; METAL-ORGANIC FRAMEWORKS ; LIGHT-EMITTING DIODES ; NITROGEN STARVATION ; CHLAMYDOMONAS-REINHARDTII ; TRANSCRIPTION FACTOR ; UNICELLULAR ALGA |
| WOS研究方向 | Biotechnology & Applied Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:001406826800001 |
| 资助机构 | Joint Funds of the National Natural Science Foundation of China ; Shandong Province ; National Natural Science Foundation of China ; International Partnership Program of Chinese Academy of Sciences ; Shandong Natural Science Foundation ; Innovation & Entrepreneurship Project of Shandong Green Industry and Environmental Security Innovation and Entrepreneurship Community ; Science & Technology Specific Projects in Agricultural High-tech Industrial Demonstration Area of the Yellow River Delta |
| 源URL | [http://ir.yic.ac.cn/handle/133337/40461]  |
| 专题 | 海岸带生物学与生物资源利用重点实验室 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 通讯作者 | Qin, Song |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Biol Resource Utilizat, Yantai 264003, Shandong, Peoples R China 2.Yantai Inst Technol, Coll Food & Bioengn, Yantai 264003, Shandong, Peoples R China 3.Shanxi Agr Univ, Inst Mol Agr & Bioenergy, Coll Agr, Taigu 030801, Shanxi, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cui, Hongli,Zhu, Xiaoli,Yu, Xiao,et al. Advancements of astaxanthin production in Haematococcus pluvialis: Update insight and way forward[J]. BIOTECHNOLOGY ADVANCES,2025,79:33. |
| APA | Cui, Hongli.,Zhu, Xiaoli.,Yu, Xiao.,Li, Siming.,Wang, Kang.,...&Qin, Song.(2025).Advancements of astaxanthin production in Haematococcus pluvialis: Update insight and way forward.BIOTECHNOLOGY ADVANCES,79,33. |
| MLA | Cui, Hongli,et al."Advancements of astaxanthin production in Haematococcus pluvialis: Update insight and way forward".BIOTECHNOLOGY ADVANCES 79(2025):33. |
入库方式： OAI收割
来源：烟台海岸带研究所
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