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Enriched pathways in gut microbiome predict response to immune checkpoint inhibitor treatment across demographic regions and various cancer types

文献类型：期刊论文

作者Cai, Xunhui8; Cho, Jennifer Y.6,7; Chen, Lijun8; Liu, Yufeng5; Ji, Fenghu5; Salgado, Katia7; Ge, Siyi7; Yang, Dehua4; Yu, Hui2,3; Shao, Jianbo3
刊名ISCIENCE
出版日期2025-04-18
卷号28期号:4页码:21
DOI10.1016/j.isci.2025.112162
通讯作者Zhang, Jianjun(jzhang20@mdanderson.org) ; Hsiao, Ansel(ansel.hsiao@ucr.edu) ; Xia, Tian(tianxia@hust.edu.cn)
英文摘要Understanding the effect of gut microbiota function on immune checkpoint inhibitor (ICI) responses is urgently needed. Here, we integrated 821 fecal metagenomes from 12 datasets to identify differentially abundant genes and construct random forest models to predict ICI response. Gene markers demonstrated excellent predictive performance, with an average area under the curve (AUC) of 0.810. Pathway analyses revealed that quorum sensing (QS), ABC transporters, flagellar assembly, and amino acid biosynthesis pathways were enriched between responders (R) and non-responders (NRs) across 12 datasets. Furthermore, luxS, manA, fliC, and trpB exhibited consistent changes between R and NR across 12 datasets. Follow-up microbiota transplant experiments showed that inter-species signaling by different QS autoinducer-2 (AI-2) molecules (synthesized by luxS) can act on overall community function to promote the colonization of Akkermansia muciniphila, which is associated with superior ICI responses. Together, our data highlight the role of gut micro- biota function in modulating the microbiome and antitumor immunity.
WOS关键词ANTI-PD1 TREATMENT ; ABC TRANSPORTERS ; MELANOMA ; IMMUNOTHERAPY ; LUMINESCENCE ; METABOLITES ; EFFICACY
资助项目National Natural Science Foundation of China[61571202] ; National Institute of Allergy and Infectious Diseases[AI157106] ; National Institute of General Medical Sciences[GM124724]
WOS研究方向Science & Technology - Other Topics
语种英语
WOS记录号WOS:001448464100001
出版者CELL PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/316701]  
专题中国科学院上海药物研究所
通讯作者Zhang, Jianjun; Hsiao, Ansel; Xia, Tian
作者单位1.Univ Texas MD Anderson Canc Ctr, Dept Genom Med, Houston, TX USA
2.Huazhong Univ Sci & Technol, Tongji Hosp, Wuhan, Peoples R China
3.Wuhan Childrens Hosp, Clin Lab, Wuhan, Peoples R China
4.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Med, Shanghai, Peoples R China
5.Huazhong Univ Sci & Technol, Sch Artificial Intelligence & Automat, Wuhan, Peoples R China
6.Univ Calif Riverside, Dept Biochem, Riverside, CA USA
7.Univ Calif Riverside, Dept Microbiol & Plant Pathol, Riverside, CA 92521 USA
8.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Inst Pathol,Dept Pathol,Sch Basic Med, Wuhan, Peoples R China
9.Harvard Med Sch, Dept Immunol, Boston, MA USA
10.Baylor Coll Med, Dept Med, Houston, TX USA
推荐引用方式
GB/T 7714		 Cai, Xunhui,Cho, Jennifer Y.,Chen, Lijun,et al. Enriched pathways in gut microbiome predict response to immune checkpoint inhibitor treatment across demographic regions and various cancer types[J]. ISCIENCE,2025,28(4):21.
APA Cai, Xunhui.,Cho, Jennifer Y..,Chen, Lijun.,Liu, Yufeng.,Ji, Fenghu.,...&Xia, Tian.(2025).Enriched pathways in gut microbiome predict response to immune checkpoint inhibitor treatment across demographic regions and various cancer types.ISCIENCE,28(4),21.
MLA Cai, Xunhui,et al."Enriched pathways in gut microbiome predict response to immune checkpoint inhibitor treatment across demographic regions and various cancer types".ISCIENCE 28.4(2025):21.

入库方式： OAI收割

来源：上海药物研究所

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