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Clerochinoids A-H, aromatic abietane diterpenoids with cytotoxic activity from the roots and stems of Clerodendrum chinense

文献类型：期刊论文

作者Chen, Jieting1,3; Liu, Zhilong1,3; Huang, Yuepei1,3; Huang, Yushi1,3; Peng, Lihua2; Qiao, Weilin2; Li, Wei1,3; Guo, De-an1,3
刊名PHYTOCHEMISTRY
出版日期2025-07-01
卷号235页码:8
关键词Clerodendrum chinense aromatic abietane diterpenoid ECD calculation Cytotoxic activity
ISSN号0031-9422
DOI10.1016/j.phytochem.2025.114474
通讯作者Li, Wei(liwei1@simm.ac.cn) ; Guo, De-an(daguo@simm.ac.cn)
英文摘要Eight previously undescribed aromatic abietane diterpenoids, clerochinoids A-H (1-8), including seven 17(15 -> 16)-abeo-abietanes (1-7) and one 17(15 -> 16),18(4 -> 3)-diabeo-abietane (8), along with 12 known analogues (9-20) were isolated from the roots and stems of Clerodendrum chinense. Their structures were elucidated by extensive spectroscopic data analysis, X-ray crystallography, and ECD calculations. All the compounds were screened for their cytotoxic activity against two human non-small cell lung cancer cell lines, H1975 and HCC827. Compounds 3, 9, 10, 12-14, 16, 17, 18, and 20 exhibited enhanced activity compared to the positive control, gefitinib. The succinct structure-activity relationship of these abietane diterpenoids was also discussed.
资助项目Qi-Huang Chief Scientist Project of the National Administration of Traditional Chinese Medicine
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
WOS记录号WOS:001447171900001
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/316707]  
专题中国科学院上海药物研究所
通讯作者Li, Wei; Guo, De-an
作者单位1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China
2.Zhongshan Zhongzhi Pharmaceut Grp Co Ltd, Zhongshan 528400, Peoples R China
3.Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Peoples R China
推荐引用方式
GB/T 7714		 Chen, Jieting,Liu, Zhilong,Huang, Yuepei,et al. Clerochinoids A-H, aromatic abietane diterpenoids with cytotoxic activity from the roots and stems of Clerodendrum chinense[J]. PHYTOCHEMISTRY,2025,235:8.
APA Chen, Jieting.,Liu, Zhilong.,Huang, Yuepei.,Huang, Yushi.,Peng, Lihua.,...&Guo, De-an.(2025).Clerochinoids A-H, aromatic abietane diterpenoids with cytotoxic activity from the roots and stems of Clerodendrum chinense.PHYTOCHEMISTRY,235,8.
MLA Chen, Jieting,et al."Clerochinoids A-H, aromatic abietane diterpenoids with cytotoxic activity from the roots and stems of Clerodendrum chinense".PHYTOCHEMISTRY 235(2025):8.

入库方式： OAI收割

来源：上海药物研究所

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