Linaggrenoids A-I, structurally diverse lindenane sesquiterpenoids with anti-hepatic fibrosis effects from Lindera aggregata
文献类型：期刊论文
| 作者 | Li, Wen-Xian1,3,4; Gan, Lu2; Liao, Yi-Ling2; Wu, Yu-Wei1; Zhang, Bai-Hui1; Guo, De-an1,3,4 ; Li, Wei1,3,4
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| 刊名 | PHYTOCHEMISTRY
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| 出版日期 | 2025-07-01 |
| 卷号 | 235页码:10 |
| 关键词 | Lindera aggregata Lauraceae Lindenane sesquiterpenoid Anti-hepatic fibrosis activity |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2025.114477 |
| 通讯作者 | Guo, De-an(daguo@simm.ac.cn) ; Li, Wei(liwei1@simm.ac.cn) |
| 英文摘要 | Linaggrenoid A (1), a highly rearranged lindenane sesquiterpenoid, together with eight undescribed lindenane sesquiterpenoid linaggrenoids B-I (2-9) and eight known analogs (10-17), were isolated from the root tubers of Lindera aggregata. Their structures, including absolute configurations, were established using spectroscopic and computational methods, as well as single-crystal X-ray diffraction. Linaggrenoids A and H (1 and 8), featuring a 5/6/3 and 3/5/6 carbocyclic ring system, respectively, demonstrated potential as anti-hepatic fibrosis agents by suppressing the expression of fibronectin, collagen I, and alpha-smooth muscle actin in TGF-beta 1-induced LX-2 cells. |
| WOS关键词 | CHLORANTHUS ; JAPONICUS ; LACTONES ; ROOTS |
| 资助项目 | National Natural Science Foundation of China[82104020] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:001447147700001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316710]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, De-an; Li, Wei |
| 作者单位 | 1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 2.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Wen-Xian,Gan, Lu,Liao, Yi-Ling,et al. Linaggrenoids A-I, structurally diverse lindenane sesquiterpenoids with anti-hepatic fibrosis effects from Lindera aggregata[J]. PHYTOCHEMISTRY,2025,235:10. |
| APA | Li, Wen-Xian.,Gan, Lu.,Liao, Yi-Ling.,Wu, Yu-Wei.,Zhang, Bai-Hui.,...&Li, Wei.(2025).Linaggrenoids A-I, structurally diverse lindenane sesquiterpenoids with anti-hepatic fibrosis effects from Lindera aggregata.PHYTOCHEMISTRY,235,10. |
| MLA | Li, Wen-Xian,et al."Linaggrenoids A-I, structurally diverse lindenane sesquiterpenoids with anti-hepatic fibrosis effects from Lindera aggregata".PHYTOCHEMISTRY 235(2025):10. |
入库方式： OAI收割
来源：上海药物研究所
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