New Phenolic Compounds from Eucalyptus tereticornis with Antioxidant Activity
文献类型：期刊论文
| 作者 | Zhang, Yu1,3,4; Miao, Lei1; Li, Guo-Li2; Zhang, Chuan-Rui1,3,4 |
| 刊名 | CHEMISTRY & BIODIVERSITY
 |
| 出版日期 | 2025-04-01 |
| 页码 | 8 |
| 关键词 | antioxidant activity
configuration determination
|
| ISSN号 | 1612-1872 |
| DOI | 10.1002/cbdv.202500312 |
| 通讯作者 | Li, Guo-Li(liguoli929@163.com) ; Zhang, Chuan-Rui(zhangchuanrui@simm.ac.cn) |
| 英文摘要 | Fourteen phenolic compounds, comprising four sesquilignans (1-4), five flavonoids (5-9), two phenylethanol glycosides (10 and 11) together with three acylphloroglucinols (12-14), were isolated from Eucalyptus tereticornis. Their structures were elucidated through spectroscopic data analyses and electronic circular dichroism (ECD) calculations. Notably, tereticornisin A (1), phloretin 2 '-O-(6-deoxy-beta-d-glucopyranoside) (6), phloretin 2 '-O-(6-deoxy-beta-d-galactopyranoside) (7), and 2-(4-hydroxyphenyl)ethyl-[6-O-(Z)-feruloyl]-beta-d-glucopyranoside (10) were new compounds. In addition, phloretin-2 '-O-beta-d-xylopyranoside (5) was isolated and definitively assigned for the first time, despite its structure having been previously speculated based on HPLC-UV-MS/MS analysis. Eight of the isolates displayed inhibitory activity against the ABTS free radicals with IC50 values that ranged from 8.07 +/- 0.10 to 14.41 +/- 0.30 mu M, comparable to the positive control (IC50 18.12 +/- 0.21 mu M). 12-14 exhibited no antibacterial activity on methicillin-resistant Staphylococcus aureus (MRSA) strains Newman, USA300, and Mu50, and vancomycin-resistant Enterococcus faecium (VREfm) strain HS-0649. |
| WOS关键词 | FORMYL PHLOROGLUCINOL MEROTERPENOIDS ; GLOBULUS ; LIGNANS ; SESQUILIGNANS ; CONSTITUENTS ; PERFORMANCE ; GLYCOSIDES ; EXTRACTS ; LEAVES ; OIL |
| 资助项目 | Key R&D Program of Shandong Province, China ; National Natural Science Foundation of China[22177016] ; [2024CXPT028] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001457655500001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316896]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Guo-Li; Zhang, Chuan-Rui |
| 作者单位 | 1.Shandong Lab Yantai Drug Discovery, Bohai Rim Adv Res Inst Drug Discovery, Yantai, Peoples R China 2.Chongqing Three Gorges Med Coll, Chongqing Key Lab Dev & Utilizat Genuine Med Mat T, Chongqing, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 4.Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yu,Miao, Lei,Li, Guo-Li,et al. New Phenolic Compounds from Eucalyptus tereticornis with Antioxidant Activity[J]. CHEMISTRY & BIODIVERSITY,2025:8. |
| APA | Zhang, Yu,Miao, Lei,Li, Guo-Li,&Zhang, Chuan-Rui.(2025).New Phenolic Compounds from Eucalyptus tereticornis with Antioxidant Activity.CHEMISTRY & BIODIVERSITY,8. |
| MLA | Zhang, Yu,et al."New Phenolic Compounds from Eucalyptus tereticornis with Antioxidant Activity".CHEMISTRY & BIODIVERSITY (2025):8. |
入库方式： OAI收割
来源：上海药物研究所
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