ROS-responsive micelles co-loaded dexamethasone and pristimerin to restore the homeostasis of the inflammatory microenvironment for rheumatoid arthritis therapy
文献类型：期刊论文
| 作者 | Liang, Ruifeng1; Tu, Yanbei1; Hua, Peng1; Huang, Yongzhuo2 ; Chen, Meiwan1
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| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2025-06-01 |
| 卷号 | 36期号:6页码:6 |
| 关键词 | Rheumatoid arthritis Micelles Macrophages Fibroblast-like synoviocytes Osteoclastogenesis |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2024.110335 |
| 通讯作者 | Chen, Meiwan(mwchen@um.edu.mo) |
| 英文摘要 | Invasive fibroblast-like synoviocytes (FLS), inflammatory macrophages and osteoclasts are the main three contributors to rheumatoid arthritis (RA) progression by promoting synovial inflammation and destructing cartilage and bone. Targeting these three cell types for restoring the inflammatory homeostasis microenvironment may be a promising anti-RA strategy. Herein, we prepared a reactive oxygen species (ROS)-responsive micelles (DPTM) to co-load dexamethasone (DEX) and pristimerin (PRI) for RA therapy. This ROS-responsive system exhibits the following advantages: (1) It makes use of the "ELVIS" effect for passive delivery and targeting the ROS environment of RA-related cells to rapidly release the payload drugs DEX and PRI. (2) Compared with free drugs, DPTM showed stronger effect on the inhibition of RA-FLS proliferation and the promotion of RA-FLS apoptosis. Moreover, DPTM could significantly weaken the migration ability of RA-FLS as indicated by the results of wound healing assay and transwell assay. (3) DPTM exerted stronger cellular uptake and anti-inflammatory effect in M1 macrophages. (4) In the model studying receptor activator of nuclear factor kappa-B ligand (RANKL)-induced differentiation of bone marrow-derived macrophages (BMDMs) to osteoclasts, DPTM showed a stronger inhibitory activity on osteoclast formation as compared to free drugs. Taken together, these results highlighted the potential of DPTM for targeted RA therapy via inhibition of RA-FLS abnormal activation, macrophage polarization and osteoclastogenesis. (c) 2025 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. |
| WOS关键词 | NITRIC-OXIDE SYNTHASE ; NF-KAPPA-B ; ACTIVATION |
| 资助项目 | National Natural Science Foun-dation of China[82204724] ; Science and Technology De-velopment Fund, Macau SAR[0029/2023/AFJ] ; Science and Technology De-velopment Fund, Macau SAR[005/2023/SKL] ; Multi-Year Research Grant (MYRG) of University of Macau[MYRG2022-00203-ICMS] ; Multi-Year Research Grant (MYRG) of University of Macau[MYRG-GRG2023-00134-ICMS-UMDF] ; Macao Young Scholars Program |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001459941600001 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316908]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Chen, Meiwan |
| 作者单位 | 1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China 2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528437, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Ruifeng,Tu, Yanbei,Hua, Peng,et al. ROS-responsive micelles co-loaded dexamethasone and pristimerin to restore the homeostasis of the inflammatory microenvironment for rheumatoid arthritis therapy[J]. CHINESE CHEMICAL LETTERS,2025,36(6):6. |
| APA | Liang, Ruifeng,Tu, Yanbei,Hua, Peng,Huang, Yongzhuo,&Chen, Meiwan.(2025).ROS-responsive micelles co-loaded dexamethasone and pristimerin to restore the homeostasis of the inflammatory microenvironment for rheumatoid arthritis therapy.CHINESE CHEMICAL LETTERS,36(6),6. |
| MLA | Liang, Ruifeng,et al."ROS-responsive micelles co-loaded dexamethasone and pristimerin to restore the homeostasis of the inflammatory microenvironment for rheumatoid arthritis therapy".CHINESE CHEMICAL LETTERS 36.6(2025):6. |
入库方式： OAI收割
来源：上海药物研究所
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