Utilization of natural products in diverse pathogeneses of diseases associated with single or double DNA strand damage repair
文献类型：期刊论文
| 作者 | Liang, Jiali2,3; Liu, Wanqing3; Zhang, Tong3; Guo, Dean1,3 ; Gong, Jiyu2; Yang, Zizhao3,4
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| 刊名 | CHINESE MEDICINE
 |
| 出版日期 | 2025-04-07 |
| 卷号 | 20期号:1页码:21 |
| 关键词 | Single or double strands DNA damage Enzymes in DNA repair Natural products Pathogeneses Clinical treatment strategy of DNA damage involved maladies |
| ISSN号 | 1749-8546 |
| DOI | 10.1186/s13020-025-01089-y |
| 通讯作者 | Gong, Jiyu(gjy0431@126.com) ; Yang, Zizhao(zzyang@shutcm.edu.cn) |
| 英文摘要 | The appearance of DNA damage often involves the participation of related enzymes, which can affect the onset and development of various diseases. Several natural active compounds have been found to efficiently adjust the activity of crucial enzymes associated with single or double-strand DNA damage, thus demonstrating their promise in treating diseases. This paper provides an in-depth examination and summary of these modulation mechanisms, leading to a thorough review of the subject. The connection between natural active compounds and disease development is explored through an analysis of the structural characteristics of these compounds. By reviewing how different scholarly sources describe identical structures using varied terminology, this study also delves into their effects on enzyme regulation. This review offers an in-depth examination of how natural active compounds can potentially be used therapeutically to influence key enzyme activities or expression levels, which in turn can affect the process of DNA damage repair (DDR). These natural compounds have been shown to not only reduce the occurrence of DNA damage but also boost the efficiency of repair processes, presenting new therapeutic opportunities for conditions such as cancer and other disease pathologies. Future research should focus on clarifying the exact mechanisms of these compounds to maximize their clinical utility and support the creation of novel approaches for disease prevention and treatment. |
| WOS关键词 | NUCLEOTIDE EXCISION-REPAIR ; SENSITIZES CANCER-CELLS ; RETIGERIC ACID B ; XERODERMA-PIGMENTOSUM ; HOMOLOGOUS RECOMBINATION ; TRANSLESION SYNTHESIS ; POLYMERASE-ETA ; BREAK REPAIR ; ISOFLAVONE GENISTEIN ; COCKAYNE-SYNDROME |
| 资助项目 | National Natural Science Foundation of China |
| WOS研究方向 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:001463753700001 |
| 出版者 | BMC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/316995]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Gong, Jiyu; Yang, Zizhao |
| 作者单位 | 1.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 2.Changchun Univ Chinese Med, Sch Pharmaceut Sci, Changchun 130117, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 4.Shanghai Univ Tradit Chinese Med, Peoples Hosp 7, Ctr Lab Anim Serv & Expt, Shanghai 200137, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Jiali,Liu, Wanqing,Zhang, Tong,et al. Utilization of natural products in diverse pathogeneses of diseases associated with single or double DNA strand damage repair[J]. CHINESE MEDICINE,2025,20(1):21. |
| APA | Liang, Jiali,Liu, Wanqing,Zhang, Tong,Guo, Dean,Gong, Jiyu,&Yang, Zizhao.(2025).Utilization of natural products in diverse pathogeneses of diseases associated with single or double DNA strand damage repair.CHINESE MEDICINE,20(1),21. |
| MLA | Liang, Jiali,et al."Utilization of natural products in diverse pathogeneses of diseases associated with single or double DNA strand damage repair".CHINESE MEDICINE 20.1(2025):21. |
入库方式： OAI收割
来源：上海药物研究所
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