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Advances in Sampling and Analytical Techniques for Single-Cell Metabolomics: Exploring Cellular Heterogeneity

文献类型：期刊论文

作者Shen, Xinxin5; Zhang, Fangyuan1,2; Tang, Chunping4; Sokovic, Marina3; Misic, Danijela3; Xu, Hongxi5; Ye, Yang4,5; Liu, Jia1,2
刊名RAPID COMMUNICATIONS IN MASS SPECTROMETRY
出版日期2025-07-15
卷号39期号:13页码:14
关键词cell isolation mass spectrometry imaging metabolite detection sampling techniques single-cell metabolomics
ISSN号0951-4198
DOI10.1002/rcm.10045
通讯作者Xu, Hongxi(xuhongxi88@gmail.com) ; Ye, Yang(yye@simm.ac.cn) ; Liu, Jia(jia.liu@simm.ac.cn)
英文摘要Single-cell metabolomics is an emerging and powerful technology that uncovers intercellular heterogeneity and reveals microenvironmental dynamics in both physiological and pathological conditions. This technology enables detailed observations of cellular interactions, providing valuable insights into processes such as aging, immune responses, and disease development. Despite significant advances, the need for detailed discussions on sampling and analytical methods in single-cell metabolomics continues to grow, with increasing focus on selecting the most suitable techniques for diverse research objectives. This review addresses these challenges by exploring key sampling and analytical strategies used in single-cell metabolomics. We focus on three main approaches: the capture and isolation of specific cell types, the precise aspiration of individual cells, and in situ mass spectrometry imaging. These methods are critically assessed to highlight strategies for achieving accurate metabolite detection at the single-cell level across diverse research applications.
WOS关键词RESOLUTION ; REVEAL ; OMICS
资助项目National Natural Science Foundation of China ; National Key R&D Program Strategic Scientific and Technological Innovation Cooperation Key Project[2022YFE0203600] ; Ministry of Science and Technology ; [82373827]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry ; Spectroscopy
语种英语
WOS记录号WOS:001465833000001
出版者WILEY
源URL[http://119.78.100.183/handle/2S10ELR8/317422]  
专题中国科学院上海药物研究所
通讯作者Xu, Hongxi; Ye, Yang; Liu, Jia
作者单位1.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China
3.Univ Belgrade, Inst Biol Res Sinisa Stankovic, China Serbia Belt & Rd Joint Lab Nat Prod & Drug D, Belgrade, Serbia
4.Chinese Acad Sci, Shanghai Inst Mat Med, China Serbia Belt & Rd Joint Lab Nat Prod & Drug D, Shanghai, Peoples R China
5.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Shen, Xinxin,Zhang, Fangyuan,Tang, Chunping,et al. Advances in Sampling and Analytical Techniques for Single-Cell Metabolomics: Exploring Cellular Heterogeneity[J]. RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2025,39(13):14.
APA Shen, Xinxin.,Zhang, Fangyuan.,Tang, Chunping.,Sokovic, Marina.,Misic, Danijela.,...&Liu, Jia.(2025).Advances in Sampling and Analytical Techniques for Single-Cell Metabolomics: Exploring Cellular Heterogeneity.RAPID COMMUNICATIONS IN MASS SPECTROMETRY,39(13),14.
MLA Shen, Xinxin,et al."Advances in Sampling and Analytical Techniques for Single-Cell Metabolomics: Exploring Cellular Heterogeneity".RAPID COMMUNICATIONS IN MASS SPECTROMETRY 39.13(2025):14.

入库方式： OAI收割

来源：上海药物研究所

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