Monte Carlo simulation-based risk assessment of human exposure to multi-mycotoxins in Platycladi semen
文献类型：期刊论文
| 作者 | Fang, Ling1,2; Liu, Xiaokang2; Feng, Lin2; Liu, Kangnan2; Li, Zhenwei2; An, Yaling2; Zhang, Daidi2; Yang, Wenzhi1; Guo, De-an1,2,3
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| 刊名 | JOURNAL OF CHROMATOGRAPHY A
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| 出版日期 | 2025-06-21 |
| 卷号 | 1751页码:9 |
| 关键词 | Platycladi semen Multi-mycotoxins UPLC-MS/MS Human exposure risk assessment Monte Carlo simulation |
| ISSN号 | 0021-9673 |
| DOI | 10.1016/j.chroma.2025.465922 |
| 通讯作者 | Guo, De-an(daguo@simm.ac.cn) |
| 英文摘要 | Mycotoxin contamination in Platycladi semen has become an increasing concern worldwide due to its significant threat to public health. In this study, a modified QuEChERS-based UPLC-MS/MS method was established to detect multi-mycotoxins in 190 batches of Platycladi semen samples obtained from various channels in China. Out of these samples, 188 tested positive for one or more mycotoxins, with an incidence of 98.95 %. Alternariol monomethyl ether was the most commonly detected with an incidence rate of 92.63 %, followed by fumonisin B2 at 91.58 % and sterigmatocystin at 87.89 %. Notably, the aflatoxin B1 contents in 26 samples and the total aflatoxins contents in 18 samples exceeded their respective official maximum residue limits. Given the toxicity and high contamination levels of mycotoxins, the risk of human exposure to them via the consumption of Platycladi semen was assessed using Monte Carlo simulation-based probabilistic models. The risk assessment using the margin of exposure and hazard quotient approach indicated that Platycladi semen is particularly susceptible to aflatoxins and sterigmatocystin, which pose significant threats to human health. This study provides the regulatory authority with a powerful platform for monitoring multi-mycotoxins in Platycladi semen, offering valuable data to safeguard consumers from potential health risks associated with mycotoxin contamination. |
| WOS关键词 | SUBSTANCES ; FOOD |
| 资助项目 | National Natural Science Foundation of China[82130111] ; Qi-Huang Chief Scientist Project of National Administration of Traditional Chinese Medicine |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:001466455900001 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/317464]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, De-an |
| 作者单位 | 1.Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Tianjin 301617, Peoples R China 2.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan 528400, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Engn Res Ctr TCM Standardizat Technol, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fang, Ling,Liu, Xiaokang,Feng, Lin,et al. Monte Carlo simulation-based risk assessment of human exposure to multi-mycotoxins in Platycladi semen[J]. JOURNAL OF CHROMATOGRAPHY A,2025,1751:9. |
| APA | Fang, Ling.,Liu, Xiaokang.,Feng, Lin.,Liu, Kangnan.,Li, Zhenwei.,...&Guo, De-an.(2025).Monte Carlo simulation-based risk assessment of human exposure to multi-mycotoxins in Platycladi semen.JOURNAL OF CHROMATOGRAPHY A,1751,9. |
| MLA | Fang, Ling,et al."Monte Carlo simulation-based risk assessment of human exposure to multi-mycotoxins in Platycladi semen".JOURNAL OF CHROMATOGRAPHY A 1751(2025):9. |
入库方式： OAI收割
来源：上海药物研究所
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